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Literature summary for 3.4.11.7 extracted from
- Purification and partial characterization of aminopeptidase A from the serum of pregnant and non-pregnant women (1984), Biochim. Biophys. Acta, 789, 324-333.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Sodium azide | - |
Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.091 | 1.2 | Glu-beta-naphthylamide | value depending on source of enzyme and presence of divalent cations | Homo sapiens | |
| 0.72 | 0.846 | Asp-beta-naphthylamide | maternal and normal serum | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ba2+ | activation | Homo sapiens | |
| Ca2+ | activation | Homo sapiens | |
| Sr2+ | activation | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 260000 | - |
gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | maternal and non-maternal | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, or room temperature, or -18°C, without Ba2+ | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Asp-beta-naphthylamide + H2O | - |
Homo sapiens | Asp + naphthylamine | - |
? | |
| Glu-beta-naphthylamide + H2O | - |
Homo sapiens | Glu + naphthylamine | - |
? | |
| additional information | slow hydrolysis of Ala-beta-naphthylamide, Arg-beta-naphthylamide | Homo sapiens | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 65 | - |
41-45% activity | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.75 | 7.25 | activity in Tris-HCl buffer higher than in phosphate buffer | Homo sapiens |
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