Literature summary for 3.4.11.6 extracted from

Petrov, V.V.; Fagard, R.H.; Lijnen, P.J.
Arginine-aminopeptidase in rat cardiac fibroblastic cells participates in angiotensin peptide turnover (2004), Cardiovasc. Res., 61, 724-735.

Search for more literature for 3.4.11.6

Activating Compound

Activating Compound	Comment	Organism	Structure
TGF-beta1	activates aminopeptidase activity	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
actinonin	40% inhibition at 0.0003 mM, independent on TGF-beta1 activation	Rattus norvegicus
amastatin	50-70% inhibition at 0.0003 mM, dependent on TGF-beta1 activation	Rattus norvegicus
arphamenine A	aminopeptidase B-specific inhibitor	Rattus norvegicus
bestatin	strong inhibition	Rattus norvegicus
L-Arg-2-naphthylamide	competitive inhibition of hydrolysis of L-Ala-2-naphthylamide, no inhibition vice versa	Rattus norvegicus
leuhistin	40% inhibition at 0.0003 mM, independent on TGF-beta1 activation	Rattus norvegicus
additional information	no or poor inhibition of L-Arg-2-naphthylamide hydrolysis by puromycin at 1 mM, aprotinin, pepstatin A, E64, chymostatin, imipramine, phosphoramidon, lisinopril, and apstatin	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-
extracellular	-	Rattus norvegicus	-	-
membrane	-	Rattus norvegicus	16020	-
additional information	subcellular localization, overview	Rattus norvegicus	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Cl-	activates	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	cardiac, ventricular	Rattus norvegicus	-
heart	cardiac ventricular fibroblastic cell	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Ala-2-naphthylamide + H2O	-	Rattus norvegicus	L-Ala + 2-naphthylamine	-	?
L-Ala-4-nitroanilide + H2O	-	Rattus norvegicus	L-Ala + 4-nitroaniline	-	?
L-Arg-2-naphthylamide + H2O	-	Rattus norvegicus	L-Arg + 2-naphthylamine	-	?
L-Arg-4-nitroanilide + H2O	-	Rattus norvegicus	L-Arg + 4-nitroaniline	-	?
L-Lys-2-naphthylamide + H2O	-	Rattus norvegicus	L-Lys + 2-naphthylamine	-	?
L-Lys-4-nitroanilide + H2O	-	Rattus norvegicus	L-Lys + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
Ap-B	-	Rattus norvegicus
Arg-AP	-	Rattus norvegicus
arginine-aminopeptidase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	-	assay at	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	-	Rattus norvegicus

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Release 2023.1 (January 2023)