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Literature summary for 3.4.11.24 extracted from

  • Ben-Meir, D.; Spungin, A.; Ashkenazi, R.; Blumberg, S.
    Specificity of Streptomyces griseus aminopeptidase and modulation of activity by divalent metal ion binding and substitution (1993), Eur. J. Biochem., 212, 107-112.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Streptomyces griseus
additional information nonchelating 1,7-phenanthroline has little effect on the activity Streptomyces griseus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Streptomyces griseus
0.53
-
L-Val-4-nitroanilide pH 8.0, 30°C Streptomyces griseus
0.58
-
L-Leu-4-nitroanilide pH 8.0, 30°C Streptomyces griseus
4.08
-
L-Ala-4-nitroanilide pH 8.0, 30°C Streptomyces griseus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates, binds to the enzyme, activation level with different enzyme substrates, overview Streptomyces griseus
additional information substitution of the Zn2+ ion by Mn2+ or Co2+ results in altered substrate specificity, e.g. the Co2+ containing enzyme highly prefers L-alanine-4-nitroanilide Streptomyces griseus
Zn2+ metalloprotease, dependent on Streptomyces griseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptide + H2O Streptomyces griseus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces griseus
-
enzyme purified from commercial product
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation protease type XIV i.e. pronase E, a protease mixture form Streptomyces griseus Streptomyces griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-4-nitroanilide + H2O
-
Streptomyces griseus L-Ala + 4-nitroaniline
-
?
L-alanine-4-nitroanilide + H2O good substrate Streptomyces griseus L-alanine + 4-nitroaniline
-
?
L-leucine-4-nitroanilide + H2O best of the amino acid 4-nitroanilide substrates Streptomyces griseus L-leucine + 4-nitroaniline
-
?
L-lysine-4-nitroanilide + H2O good substrate Streptomyces griseus L-lysine + 4-nitroaniline
-
?
L-methionine-4-nitroanilide + H2O very good substrate Streptomyces griseus L-methionine + 4-nitroaniline
-
?
L-phenylalanine-4-nitroanilide + H2O very good substrate Streptomyces griseus L-phenylalanine + 4-nitroaniline
-
?
L-proline-4-nitroanilide + H2O good substrate Streptomyces griseus L-proline + 4-nitroaniline
-
?
L-valine-4-nitroanilide + H2O good substrate Streptomyces griseus L-valine + 4-nitroaniline
-
?
additional information no activity with Gly-Pro-4-nitroanilide and Ala-Pro-4-nitroanilide, no acitivity with Xaa-Pro N-terminal sequences, glycine-4-nitroanilide and acidic amino acid 4-nitroanilide are very poor substrates Streptomyces griseus ?
-
?
peptide + H2O
-
Streptomyces griseus ?
-
?

Synonyms

Synonyms Comment Organism
M28.003 Merops-ID Streptomyces griseus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Streptomyces griseus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.191
-
L-Val-4-nitroanilide pH 8.0, 30°C Streptomyces griseus
1.71
-
L-Ala-4-nitroanilide pH 8.0, 30°C Streptomyces griseus
2.94
-
L-Ala-4-nitroanilide pH 8.0, 30°C Streptomyces griseus
391
-
L-Leu-4-nitroanilide pH 8.0, 30°C Streptomyces griseus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Streptomyces griseus