Application | Comment | Organism |
---|---|---|
medicine | exposure of human peripheral blood mononuclear cells to isoform ERAP1 polymorphic variant proteins as well as ERAP1 overexpression increases inflammatory cytokine and chemokine production, and enhances immune cell activation. ERAP1 is able to activate innate immunity via multiple pathways, including the NOD-like receptor NLRP3 inflammasome. These responses vary if autoimmune disease-associated variants of ERAP1 are examined in the assay systems. Blocking ERAP1 cellular internalization augments IL-1beta production | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NZ08 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|
General Information | Comment | Organism |
---|---|---|
physiological function | exposure of human peripheral blood mononuclear cells to isoform ERAP1 polymorphic variant proteins as well as ERAP1 overexpression increases inflammatory cytokine and chemokine production, and enhances immune cell activation. ERAP1 is able to activate innate immunity via multiple pathways, including the NOD-like receptor NLRP3 inflammasome. These responses vary if autoimmune disease-associated variants of ERAP1 are examined in the assay systems. Blocking ERAP1 cellular internalization augments IL-1beta production | Homo sapiens |