Cloned (Comment) | Organism |
---|---|
expression in RAW264.7 cell | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
105000 | - |
x * 105000, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9EQH2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Subunits | Comment | Organism |
---|---|---|
? | x * 105000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
ERAP1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | in the presence of aminopeptidase inhibitor amastatin, nitric oxide synthesis in activated RAW264.7 cells is significantly decreased. Subsequently, significant reduction of nitric oxide synthesis is observed in aminopeptidase ERAP1 knockdown cells compared with wild-type cells. This reduction is rescued by exogenously added ERAP1. When peritoneal macrophages prepared from ERAP1 knockout mouse are employed, reduction of nitric oxide synthesis in knockout mouse macrophages is also attributable to ERAP1. In the presence of amastatin, further reduction is observed in knockout mouse-derived macrophages | Mus musculus |