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Literature summary for 3.4.11.22 extracted from

  • Kochan, G.; Krojer, T.; Harvey, D.; Fischer, R.; Chen, L.; Vollmar, M.; von Delft, F.; Kavanagh, K.L.; Brown, M.A.; Bowness, P.; Wordsworth, P.; Kessler, B.M.; Oppermann, U.
    Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming (2011), Proc. Natl. Acad. Sci. USA, 108, 7745-7750.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
His-tagged protein expressed in insect cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion method Homo sapiens

Protein Variants

Protein Variants Comment Organism
K528R less efficient in peptide processing suggesting a defect in the catalytic process, also a naturally occuring mutation associated with reduced ankylosing spondylitis risk Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from culture medium, immobilized metal ion affinity chromatography (Ni2+), gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
QITANRELIQQEL + H2O
-
 Homo sapiens ? + TANRELIQQEL intermediate product TANRELIQQEL is further processed ?

Synonyms

Synonyms Comment Organism
endoplasmic reticulum aminopeptidase 1
-
 Homo sapiens
ERAP1
-
 Homo sapiens