Literature summary for 3.4.11.2 extracted from

Cai, J.; Kehoe, O.; Smith, G.M.; Hykin, P.; Boulton, M.E.
The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy (2008), Invest. Ophthalmol. Vis. Sci., 49, 2163-2171.

Search for more literature for 3.4.11.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	angiopoietin-1 enhances CD13 expression in a dose-dependent manner	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	Tie-2 antisense (but not Tie-2 sense) treatment significantly reduces CD13 expression and abolishes angiopoieting-1-induced CD13 expression in pericytes	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	dependent on	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
150000	-	SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pericyte	retinal pericyte	Homo sapiens	-
retina	retinal pericyte	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Ala-p-nitroanilide + H2O	-	Homo sapiens	L-Ala + p-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
aminopeptidase N	-	Homo sapiens
CD13	-	Homo sapiens

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Release 2023.1 (January 2023)