Any feedback?
Literature summary for 3.4.11.2 extracted from
- Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design (2008), Curr. Med. Chem., 15, 2850-2865.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (1-amino-2-cyclohexylethyl)phosphonic acid | - |
Homo sapiens |  |
| (1-amino-2-cyclopentylethyl)phosphonic acid | - |
Homo sapiens | |
| (1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid | - |
Homo sapiens | |
| (1-amino-3-cyclohexylpropyl)phosphonic acid | - |
Homo sapiens | |
| (1-amino-3-cyclopentylpropyl)phosphonic acid | - |
Homo sapiens | |
| (1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid | - |
Homo sapiens | |
| (1-amino-3-methylbutyl)(1-hydroxypentyl)phosphinic acid | - |
Homo sapiens | |
| (1-amino-3-methylbutyl)(2-benzyl-3-oxo-3-phenylpropyl)phosphinic acid | - |
Homo sapiens | |
| (1-amino-3-methylbutyl)phosphinic acid | - |
Homo sapiens | |
| (1-amino-3-methylbutyl)[amino(phenyl)methyl]phosphinic acid | - |
Homo sapiens | |
| (1-amino-3-phenylbutyl)phosphonic acid | - |
Homo sapiens | |
| (1-amino-3-phenylpropyl)(2-benzyl-3-oxo-3-phenylpropyl)phosphinic acid | - |
Homo sapiens | |
| (1-amino-3-phenylpropyl)phosphinic acid | - |
Homo sapiens | |
| (1-amino-4-cyclohexylbutyl)phosphonic acid | - |
Homo sapiens | |
| (1-amino-5-phenylpentyl)phosphonic acid | - |
Homo sapiens | |
| (1-aminobutyl)(1-amino-3-methylbutyl)phosphinic acid | - |
Homo sapiens | |
| (1-aminobutyl)[amino(phenyl)methyl]phosphinic acid | - |
Homo sapiens | |
| (1-aminoethyl)(1-amino-3-methylbutyl)phosphinic acid | - |
Homo sapiens | |
| (1-aminoethyl)(2-benzyl-3-oxo-3-phenylpropyl)phosphinic acid | - |
Homo sapiens | |
| (1-aminoethyl)[amino(phenyl)methyl]phosphinic acid | - |
Homo sapiens | |
| (1-benzyl-1H-imidazol-4-yl)methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucylalaninate | - |
Homo sapiens | |
| (2E)-3-[(1-aminoethyl)(hydroxy)phosphoryl]-2-methylprop-2-enoic acid | - |
Homo sapiens | |
| (2S,3R)-3-amino-2-hydroxy-4-phenyl-N-1,3-thiazol-2-ylbutanamide | - |
Homo sapiens | |
| (2S,3R)-3-amino-2-hydroxy-N-1H-imidazo[4,5-c]pyridin-4-yl-4-phenylbutanamide | - |
Homo sapiens | |
| (2S,3R)-3-amino-N-(2,6-dihydroxypyrimidin-4-yl)-2-hydroxy-4-phenylbutanamide | - |
Homo sapiens | |
| (2S,3R)-3-amino-N-(5-amino-1,3-thiazol-2-yl)-2-hydroxy-4-phenylbutanamide | - |
Homo sapiens | |
| (2S,3R)-3-amino-N-1,3-benzothiazol-2-yl-2-hydroxy-4-phenylbutanamide | - |
Homo sapiens | |
| (2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one O-(2-phenylethyl)oxime hydrochloride | - |
Homo sapiens | |
| (2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one O-(3-phenylpropyl)oxime hydrochloride | - |
Homo sapiens | |
| (2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one O-(4-phenylbutyl)oxime hydrochloride | - |
Homo sapiens | |
| (2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one O-benzyloxime hydrochloride | - |
Homo sapiens | |
| (2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one O-methyloxime hydrochloride | - |
Homo sapiens | |
| (2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one oxime hydrochloride | - |
Homo sapiens | |
| (3S)-3-(D-alanylamino)-2-([[(1S)-1-aminoethyl][(3r)-tricyclo[3.3.1.13,7]dec-1-yloxy]phosphoryl]methyl)-5-methylhexanoic acid | - |
Homo sapiens | |
| (3S)-N-hydroxy-2-(phenylsulfonyl)-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxamide | - |
Homo sapiens | |
| (3S)-N-hydroxy-2-(phenylsulfonyl)-6,11-dioxa-2-azaspiro[4.6]undecane-3-carboxamide | - |
Homo sapiens | |
| (3S)-N-hydroxy-2-(phenylsulfonyl)-6,12-dioxa-2-azaspiro[4.7]dodecane-3-carboxamide | - |
Homo sapiens | |
| (3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxamide | - |
Homo sapiens | |
| (3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,11-dioxa-2-azaspiro[4.6]undecane-3-carboxamide | - |
Homo sapiens | |
| (3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,12-dioxa-2-azaspiro[4.7]dodecane-3-carboxamide | - |
Homo sapiens | |
| (4R)-4-(hexanoylamino)-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide | - |
Homo sapiens | |
| (4R)-4-[[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide | - |
Homo sapiens | |
| (aminomethyl)(1-amino-3-methylbutyl)phosphinic acid | - |
Homo sapiens | |
| (aminomethyl)[amino(phenyl)methyl]phosphinic acid | - |
Homo sapiens | |
| 1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride | - |
Homo sapiens | |
| 1,4-dihydro-3H-isochromen-3-one | - |
Homo sapiens | |
| 1,4-dihydro-3H-isothiochromen-3-one | - |
Homo sapiens | |
| 1-(3-amino-1,2,3,4-tetrahydronaphthalen-2-yl)ethanone hydrochloride | - |
Homo sapiens | |
| 1-amino-2-methylpropyl(benzylcarbamoyl)phosphinic acid | - |
Homo sapiens | |
| 1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid | - |
Homo sapiens | |
| 1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid | - |
Homo sapiens | |
| 1-amino-2-methylpropyl(phenylcarbamoyl)phosphinic acid | - |
Homo sapiens | |
| 1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid | - |
Homo sapiens | |
| 1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid | - |
Homo sapiens | |
| 1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid | - |
Homo sapiens | |
| 1-amino-4-methylpentyl(benzylcarbamoyl)phosphinic acid | - |
Homo sapiens | |
| 1-amino-4-methylpentyl(phenylcarbamoyl)phosphinic acid | - |
Homo sapiens | |
| 1-aminobutyl(4-methoxybenzylcarbamothioyl)phosphinic acid | - |
Homo sapiens | |
| 1-aminobutyl(phenethylcarbamothioyl)phosphinic acid | - |
Homo sapiens | |
| 1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid | - |
Homo sapiens | |
| 1-aminoethyl(phenethylcarbamothioyl)phosphinic acid | - |
Homo sapiens | |
| 1-aminopentyl(4-methoxybenzylcarbamothioyl)phosphinic acid | - |
Homo sapiens | |
| 1-aminopentyl(phenethylcarbamothioyl)phosphinic acid | - |
Homo sapiens | |
| 2-([[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]amino)propaneperoxoic acid | - |
Homo sapiens | |
| 2-amino-1,4-dihydroisoquinolin-3(2H)-one | - |
Homo sapiens | |
| 2-amino-1,4-dihydrophenanthren-3(2H)-one hydrochloride | - |
Homo sapiens | |
| 2-hydroxy-1,4-dihydroisoquinolin-3(2H)-one | - |
Homo sapiens | |
| 2-[[(1-amino-3-methylbutyl)(hydroxy)phosphoryl]amino]-4-methylpentanoic acid | - |
Homo sapiens | |
| 2-[[(1-amino-3-methylbutyl)(hydroxy)phosphoryl]methyl]-4-methylpentanoic acid | - |
Homo sapiens | |
| 2-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methyl]-4-methylpentanoic acid | - |
Homo sapiens | |
| 2-{[(1-aminoethyl)(hydroxy)phosphoryl]methyl}decanoic acid | - |
Homo sapiens | |
| 3,4-dihydronaphthalen-2(1H)-one | - |
Homo sapiens | |
| 3-(hydroperoxy(hydroxy)phosphino)-1,2,3,4-tetrahydronaphthalen-2-amine | - |
Homo sapiens | |
| 3-amino-1-(2-phenylethyl)-3,4-dihydronaphthalen-2(1H)-one hydrochloride | - |
Homo sapiens | |
| 3-amino-3,4-dihydroquinolin-2(1H)-one hydrochloride | - |
Homo sapiens | |
| 3-amino-N-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxamide hydrochloride | - |
Homo sapiens | |
| 3-[(1-amino-3-methylbutyl)(hydroxy)phosphoryl]propanoic acid | - |
Homo sapiens | |
| 3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-(4-hydroxybenzyl)propanoic acid | - |
Homo sapiens | |
| 3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-benzylpropanoic acid | - |
Homo sapiens | |
| 3-[(1-aminoethyl)(hydroxy)phosphoryl]-2-methylpropanoic acid | - |
Homo sapiens | |
| 6-hydroxy-6-oxo-N-1,3-thiazol-2-yl-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide | - |
Homo sapiens | |
| 6-hydroxy-N-(methoxycarbonyl)-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide | - |
Homo sapiens | |
| 6-hydroxy-N-(methoxycarbonyl)-N-methyl-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide | - |
Homo sapiens | |
| 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-N-hydroxyglycinamide | - |
Homo sapiens | |
| actinonin | - |
Homo sapiens | |
| amastatin | - |
Homo sapiens | |
| bestatin | - |
Homo sapiens | |
| bis(1-amino-3-methylbutyl)phosphinic acid | - |
Homo sapiens | |
| bis(1-amino-3-phenylpropyl)phosphinic acid | - |
Homo sapiens | |
| bis[amino(phenyl)methyl]phosphinic acid | - |
Homo sapiens | |
| cyclohexylmethyl N-[(2S)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate | - |
Homo sapiens | |
| lapstatin | - |
Homo sapiens | |
| methyl (2S)-1-(methylsulfonyl)-4-oxopyrrolidine-2-carboxylate | - |
Homo sapiens | |
| methyl (2S)-1-[(4-methylphenyl)sulfonyl]-4-oxopyrrolidine-2-carboxylate | - |
Homo sapiens | |
| methyl (2S)-4-oxo-1-(phenylsulfonyl)pyrrolidine-2-carboxylate | - |
Homo sapiens | |
| methyl (2S,4R)-4-hydroxy-1-(methylsulfonyl)pyrrolidine-2-carboxylate | - |
Homo sapiens | |
| methyl (2S,4R)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxylate | - |
Homo sapiens | |
| methyl (2S,4R)-4-hydroxy-1-[(4-methylphenyl)sulfonyl]pyrrolidine-2-carboxylate | - |
Homo sapiens | |
| methyl (4R)-4-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinate | - |
Homo sapiens | |
| methyl 2-([[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]amino)-4-(methylperoxy)-4-oxobutanoate | - |
Homo sapiens | |
| methyl 2-chloro-N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]alaninate | - |
Homo sapiens | |
| methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-(4R)-4-(benzyloxy)prolinate | - |
Homo sapiens | |
| methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-L-methioninate | - |
Homo sapiens | |
| methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucylserinate | - |
Homo sapiens | |
| methyl bestatin | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-D-phenylalaninate | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-L-phenylalaninate | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]cysteinate | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]glycinate | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]histidinate | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]isoleucinate | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]leucinate | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]methioninate | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]threoninate | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]tryptophanate | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]tyrosinate | - |
Homo sapiens | |
| methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]valinate | - |
Homo sapiens | |
| methyl N2-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-N5-(nitrocarbamimidoyl)ornithinate | - |
Homo sapiens | |
| methyl N2-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]lysinate | - |
Homo sapiens | |
| methyl [(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetate | - |
Homo sapiens | |
| N-(4-aminophenyl)-6-hydroxy-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide | - |
Homo sapiens | |
| N-(4-chlorophenyl)-6-hydroxy-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide | - |
Homo sapiens | |
| N-hydroxy-2-(2-methylpropyl)-N'-(4-phenylbutyl)propanediamide | - |
Homo sapiens | |
| N-hydroxy-2-(naphthalen-2-ylsulfanyl)-acetamide | - |
Homo sapiens | |
| N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]benzamide | - |
Homo sapiens | |
| N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3,4,5-trimethoxybenzamide | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-(pyrazin-2-ylcarbonyl)-L-lysinamide | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-(pyridin-3-ylcarbonyl)-L-lysinamide | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-[(2E)-3-phenylprop-2-enoyl]-L-lysinamide | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-[(3-nitrophenyl)carbonyl]-L-lysinamide | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N2-[(2,4-dichlorophenyl)carbonyl]-L-lysine | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N2-[(2,4-dichlorophenyl)carbonyl]-N-hydroxy-L-lysinamide | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N2-[(2E)-3-phenylprop-2-enoyl]-L-lysine | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N2-[(3-nitrophenyl)carbonyl]-L-lysine | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N2-[(4-bromophenyl)carbonyl]-L-lysine | - |
Homo sapiens | |
| N6-[(benzyloxy)carbonyl]-N2-[(4-bromophenyl)carbonyl]-N-hydroxy-L-lysinamide | - |
Homo sapiens | |
| phebestin | - |
Homo sapiens | |
| probestin | - |
Homo sapiens | |
| tert-butyl N-[(2S)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate | - |
Homo sapiens | |
| [(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetic acid | - |
Homo sapiens | |
| [1-amino-3-(4-hydroxyphenyl)propyl]phosphonic acid | - |
Homo sapiens | |
| [amino(cyclobutyl)methyl]phosphonic acid | - |
Homo sapiens | |
| [amino(cyclohexyl)methyl]phosphonic acid | - |
Homo sapiens | |
| [amino(cyclopropyl)methyl]phosphonic acid | - |
Homo sapiens | |
| [amino(phenyl)methyl](1-amino-3-phenylpropyl)phosphinic acid | - |
Homo sapiens | |
| [amino(phenyl)methyl](1-hydroxy-3-methylbutyl)phosphinic acid | - |
Homo sapiens | |
| [amino(phenyl)methyl](1-hydroxy-3-phenylpropyl)phosphinic acid | - |
Homo sapiens | |
| [amino(phenyl)methyl](1-hydroxyethyl)phosphinic acid | - |
Homo sapiens | |
| [amino(phenyl)methyl](1-hydroxypentyl)phosphinic acid | - |
Homo sapiens | |
| [amino(phenyl)methyl][hydroxy(phenyl)methyl]phosphinic acid | - |
Homo sapiens | |
| [amino[4-(1-methylethyl)phenyl]methyl]phosphonic acid | - |
Homo sapiens | |
| [[(1-amino-3-methylbutyl)(hydroxy)phosphoryl]amino]acetic acid | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | dependent on | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 75000 | - |
2 * 75000 | Homo sapiens |
| 150000 | - |
- |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-375 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Ala-p-nitroanilide + H2O | - |
Homo sapiens | L-Ala + p-nitroaniline | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 75000 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alanine aminopeptidase | - |
Homo sapiens |
| aminopeptidase M | - |
Homo sapiens |
| aminopeptidase N | - |
Homo sapiens |
| APN | - |
Homo sapiens |
| CD13 | - |
Homo sapiens |
| GP150 | - |
Homo sapiens |
| Microsomal aminopeptidase | - |
Homo sapiens |
| p146 | - |
Homo sapiens |
| p161 | - |
Homo sapiens |
| particle-bound aminopeptidase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
actinonin | - |
Homo sapiens | |
| 0.0035 | - |
N-hydroxy-2-(naphthalen-2-ylsulfanyl)-acetamide | - |
Homo sapiens | |
| 0.00369 | - |
(1-amino-5-phenylpentyl)phosphonic acid | - |
Homo sapiens | |
| 0.0185 | - |
(1-amino-3-cyclopentylpropyl)phosphonic acid | - |
Homo sapiens | |
| 0.0237 | - |
[1-amino-3-(4-hydroxyphenyl)propyl]phosphonic acid | - |
Homo sapiens | |
| 0.0369 | - |
(1-amino-3-phenylbutyl)phosphonic acid | - |
Homo sapiens | |
| 0.0371 | - |
(1-amino-3-cyclohexylpropyl)phosphonic acid | - |
Homo sapiens | |
| 0.0416 | - |
(1-amino-4-cyclohexylbutyl)phosphonic acid | - |
Homo sapiens | |
| 0.0477 | - |
(1-amino-2-cyclopentylethyl)phosphonic acid | - |
Homo sapiens | |
| 0.0547 | - |
(1-amino-2-cyclohexylethyl)phosphonic acid | - |
Homo sapiens | |
| 0.0774 | - |
[amino(cyclobutyl)methyl]phosphonic acid | - |
Homo sapiens | |
| 0.161 | - |
[amino(cyclohexyl)methyl]phosphonic acid | - |
Homo sapiens | |
| 0.168 | - |
[amino[4-(1-methylethyl)phenyl]methyl]phosphonic acid | - |
Homo sapiens | |
| 0.178 | - |
[amino(cyclopropyl)methyl]phosphonic acid | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000009 | - |
- |
Homo sapiens | methyl (4R)-4-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinate | |
| 0.0000021 | - |
- |
Homo sapiens | (4R)-4-[[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide | |
| 0.0000077 | - |
- |
Homo sapiens | (4R)-4-(hexanoylamino)-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide | |
| 0.00002 | - |
- |
Homo sapiens | 2-amino-1,4-dihydrophenanthren-3(2H)-one hydrochloride | |
| 0.00005 | - |
- |
Homo sapiens | probestin | |
| 0.00008 | - |
- |
Homo sapiens | 3-amino-1-(2-phenylethyl)-3,4-dihydronaphthalen-2(1H)-one hydrochloride | |
| 0.00024 | - |
- |
Homo sapiens | [amino(phenyl)methyl](1-hydroxy-3-phenylpropyl)phosphinic acid | |
| 0.00025 | - |
- |
Homo sapiens | 1-aminopentyl(4-methoxybenzylcarbamothioyl)phosphinic acid | |
| 0.00038 | - |
- |
Homo sapiens | 1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid | |
| 0.0005 | - |
- |
Homo sapiens | 1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid | |
| 0.0005 | - |
- |
Homo sapiens | (1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid | |
| 0.00053 | - |
- |
Homo sapiens | 1-amino-4-methylpentyl(benzylcarbamoyl)phosphinic acid | |
| 0.00055 | - |
- |
Homo sapiens | [amino(phenyl)methyl][hydroxy(phenyl)methyl]phosphinic acid | |
| 0.0006 | - |
- |
Homo sapiens | bis[amino(phenyl)methyl]phosphinic acid | |
| 0.00068 | - |
- |
Homo sapiens | 1-aminobutyl(4-methoxybenzylcarbamothioyl)phosphinic acid | |
| 0.00071 | - |
- |
Homo sapiens | [amino(phenyl)methyl](1-amino-3-phenylpropyl)phosphinic acid | |
| 0.00073 | - |
- |
Homo sapiens | 1-aminopentyl(phenethylcarbamothioyl)phosphinic acid | |
| 0.00083 | - |
- |
Homo sapiens | bis(1-amino-3-phenylpropyl)phosphinic acid | |
| 0.00093 | - |
- |
Homo sapiens | 1-amino-2-methylpropyl(benzylcarbamoyl)phosphinic acid | |
| 0.001 | - |
- |
Homo sapiens | (1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid | |
| 0.00112 | - |
- |
Homo sapiens | 1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid | |
| 0.00118 | - |
- |
Homo sapiens | 1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid | |
| 0.0019 | - |
- |
Homo sapiens | 1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid | |
| 0.00228 | - |
- |
Homo sapiens | 1-aminobutyl(phenethylcarbamothioyl)phosphinic acid | |
| 0.003 | - |
- |
Homo sapiens | (1-amino-3-methylbutyl)(1-hydroxypentyl)phosphinic acid | |
| 0.0031 | - |
- |
Homo sapiens | N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3,4,5-trimethoxybenzamide | |
| 0.004 | - |
- |
Homo sapiens | (1-amino-3-methylbutyl)[amino(phenyl)methyl]phosphinic acid | |
| 0.0042 | - |
- |
Homo sapiens | 1-aminoethyl(phenethylcarbamothioyl)phosphinic acid | |
| 0.0052 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]histidinate | |
| 0.01056 | - |
- |
Homo sapiens | 1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid | |
| 0.011 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-D-phenylalaninate | |
| 0.012 | - |
- |
Homo sapiens | [amino(phenyl)methyl](1-hydroxy-3-methylbutyl)phosphinic acid | |
| 0.0132 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N2-[(2,4-dichlorophenyl)carbonyl]-N-hydroxy-L-lysinamide | |
| 0.0161 | - |
- |
Homo sapiens | 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-N-hydroxyglycinamide | |
| 0.0169 | - |
- |
Homo sapiens | bestatin | |
| 0.017 | - |
- |
Homo sapiens | (1-aminobutyl)[amino(phenyl)methyl]phosphinic acid | |
| 0.0189 | - |
- |
Homo sapiens | 2-([[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]amino)propaneperoxoic acid | |
| 0.0207 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]methioninate | |
| 0.0214 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]valinate | |
| 0.0217 | - |
- |
Homo sapiens | methyl 2-([[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]amino)-4-(methylperoxy)-4-oxobutanoate | |
| 0.0228 | - |
- |
Homo sapiens | 6-hydroxy-6-oxo-N-1,3-thiazol-2-yl-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide | |
| 0.0234 | - |
- |
Homo sapiens | N-(4-aminophenyl)-6-hydroxy-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide | |
| 0.0243 | - |
- |
Homo sapiens | N-(4-chlorophenyl)-6-hydroxy-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide | |
| 0.028 | - |
- |
Homo sapiens | [amino(phenyl)methyl](1-hydroxypentyl)phosphinic acid | |
| 0.0297 | - |
- |
Homo sapiens | (1-benzyl-1H-imidazol-4-yl)methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucylalaninate | |
| 0.0302 | - |
- |
Homo sapiens | methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-(4R)-4-(benzyloxy)prolinate | |
| 0.035 | - |
- |
Homo sapiens | 1-amino-4-methylpentyl(phenylcarbamoyl)phosphinic acid | |
| 0.0368 | - |
- |
Homo sapiens | methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucylserinate | |
| 0.0381 | - |
- |
Homo sapiens | methyl N2-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]lysinate | |
| 0.0384 | - |
- |
Homo sapiens | methyl (2S,4R)-4-hydroxy-1-[(4-methylphenyl)sulfonyl]pyrrolidine-2-carboxylate | |
| 0.0414 | - |
- |
Homo sapiens | 6-hydroxy-N-(methoxycarbonyl)-N-methyl-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide | |
| 0.0416 | - |
- |
Homo sapiens | methyl (2S,4R)-4-hydroxy-1-(methylsulfonyl)pyrrolidine-2-carboxylate | |
| 0.042 | - |
- |
Homo sapiens | (aminomethyl)[amino(phenyl)methyl]phosphinic acid | |
| 0.042 | - |
- |
Homo sapiens | methyl N2-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-N5-(nitrocarbamimidoyl)ornithinate | |
| 0.0431 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]tryptophanate | |
| 0.0448 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]tyrosinate | |
| 0.046 | - |
- |
Homo sapiens | (1-aminoethyl)[amino(phenyl)methyl]phosphinic acid | |
| 0.0462 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-L-phenylalaninate | |
| 0.0462 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]leucinate | |
| 0.048 | - |
- |
Homo sapiens | [amino(phenyl)methyl](1-hydroxyethyl)phosphinic acid | |
| 0.0485 | - |
- |
Homo sapiens | (3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxamide | |
| 0.0493 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]isoleucinate | |
| 0.0498 | - |
- |
Homo sapiens | [(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetic acid | |
| 0.05 | - |
- |
Homo sapiens | (1-aminobutyl)(1-amino-3-methylbutyl)phosphinic acid | |
| 0.05 | - |
- |
Homo sapiens | bis(1-amino-3-methylbutyl)phosphinic acid | |
| 0.05 | - |
- |
Homo sapiens | methyl 2-chloro-N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]alaninate | |
| 0.0503 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]cysteinate | |
| 0.0507 | - |
- |
Homo sapiens | methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-L-methioninate | |
| 0.0519 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]threoninate | |
| 0.0532 | - |
- |
Homo sapiens | 6-hydroxy-N-(methoxycarbonyl)-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide | |
| 0.0538 | - |
- |
Homo sapiens | methyl (2S,4R)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxylate | |
| 0.0549 | - |
- |
Homo sapiens | methyl (2S)-1-[(4-methylphenyl)sulfonyl]-4-oxopyrrolidine-2-carboxylate | |
| 0.0554 | - |
- |
Homo sapiens | methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]glycinate | |
| 0.0578 | - |
- |
Homo sapiens | (3S)-N-hydroxy-2-(phenylsulfonyl)-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxamide | |
| 0.0618 | - |
- |
Homo sapiens | (3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,11-dioxa-2-azaspiro[4.6]undecane-3-carboxamide | |
| 0.0634 | - |
- |
Homo sapiens | methyl [(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetate | |
| 0.0732 | - |
- |
Homo sapiens | (3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,12-dioxa-2-azaspiro[4.7]dodecane-3-carboxamide | |
| 0.0758 | - |
- |
Homo sapiens | methyl (2S)-4-oxo-1-(phenylsulfonyl)pyrrolidine-2-carboxylate | |
| 0.076 | - |
- |
Homo sapiens | (aminomethyl)(1-amino-3-methylbutyl)phosphinic acid | |
| 0.0827 | - |
- |
Homo sapiens | (3S)-N-hydroxy-2-(phenylsulfonyl)-6,11-dioxa-2-azaspiro[4.6]undecane-3-carboxamide | |
| 0.0912 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-(pyridin-3-ylcarbonyl)-L-lysinamide | |
| 0.0926 | - |
- |
Homo sapiens | methyl (2S)-1-(methylsulfonyl)-4-oxopyrrolidine-2-carboxylate | |
| 0.0943 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-(pyridin-3-ylcarbonyl)-L-lysinamide | |
| 0.0958 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-[(3-nitrophenyl)carbonyl]-L-lysinamide | |
| 0.097 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-(pyrazin-2-ylcarbonyl)-L-lysinamide | |
| 0.1067 | - |
- |
Homo sapiens | (3S)-N-hydroxy-2-(phenylsulfonyl)-6,12-dioxa-2-azaspiro[4.7]dodecane-3-carboxamide | |
| 0.1108 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N2-[(3-nitrophenyl)carbonyl]-L-lysine | |
| 0.1119 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N2-[(4-bromophenyl)carbonyl]-N-hydroxy-L-lysinamide | |
| 0.1272 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N2-[(2,4-dichlorophenyl)carbonyl]-L-lysine | |
| 0.155 | - |
- |
Homo sapiens | (1-aminoethyl)(1-amino-3-methylbutyl)phosphinic acid | |
| 0.16 | - |
- |
Homo sapiens | 1-amino-2-methylpropyl(phenylcarbamoyl)phosphinic acid | |
| 0.1668 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine | |
| 0.188 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N2-[(4-bromophenyl)carbonyl]-L-lysine | |
| 0.1974 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine | |
| 0.2151 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N2-[(2E)-3-phenylprop-2-enoyl]-L-lysine | |
| 0.2196 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine | |
| 0.5696 | - |
- |
Homo sapiens | N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-[(2E)-3-phenylprop-2-enoyl]-L-lysinamide | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
