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Literature summary for 3.4.11.2 extracted from
- Reduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC (2009), Brain Pathol., 20, 200-210.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not inhibited by PAQ-22; there is a significant reduction of APN mRNA and protein expression, as well as enzymatic activity, in high-grade meningiomas | Homo sapiens | |
| phebestin | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | dependent on | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BEN-MEN-1 cell | - |
Homo sapiens | - |
| F5 meningioma cell | - |
Homo sapiens | - |
| HBL-52 cell | - |
Homo sapiens | - |
| IOMM-Lee cell | - |
Homo sapiens | - |
| SF-3061 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Ala-p-nitroanilide + H2O | - |
Homo sapiens | L-Ala + p-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminopeptidase N | - |
Homo sapiens |
| APN | - |
Homo sapiens |
| CD13 | - |
Homo sapiens |
| mAAP | - |
Homo sapiens |
| membrane alanyl-aminopeptidase | - |
Homo sapiens |
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