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Literature summary for 3.4.11.2 extracted from

  • Krstanovic, M.; Brgles, M.; Halassy, B.; Frkanec, R.; Vrdoljak, A.; Branovic, K.; Tomasic, J.; Benedetti, F.
    Purification and characterization of L,(L/D)-aminopeptidase from guinea pig serum (2006), Prep. Biochem. Biotechnol., 36, 175-195.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
amastatin strong inhibition Cavia porcellus
bestatin strong inhibition Cavia porcellus
metal chelators strong inhibition Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.6
-
L-Ala-4-nitroanilide
-
Cavia porcellus
18
-
L-Ala-D-iso-Gln-meso-DAP(omegaNH2)-D-Ala-D-Ala
-
Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Cavia porcellus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
175000
-
gel filtration Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native L,(L/D)-aminopeptidase 700fold from serum to homogeneity in 4 chromatographic steps Cavia porcellus

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
enkephalin + H2O enkephalins comprising L,L- and L,D-peptide bonds Cavia porcellus ?
-
?
L-Ala-4-nitroanilide + H2O
-
Cavia porcellus L-Ala + 4-nitroaniline
-
?
L-Ala-D-iso-Gln-meso-DAP(omegaNH2)-D-Ala-D-Ala + H2O
-
Cavia porcellus L-Ala + D-iso-Gln-meso-DAP(omegaNH2)-D-Ala-D-Ala product identification and stereochemic determination ?
additional information the enzyme hydrolyzes several peptides with N-terminal L-amino acids, but not with N-terminal D-amino acids, no activity with L-Asp-L-Asp Cavia porcellus ?
-
?

Synonyms

Synonyms Comment Organism
L,(L/D)-aminopeptidase
-
Cavia porcellus