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Literature summary for 3.4.11.2 extracted from

  • Chang, Y.W.; Chen, S.C.; Cheng, E.C.; Ko, Y.P.; Lin, Y.C.; Kao, Y.R.; Tsay, Y.G.; Yang, P.C.; Wu, C.W.; Roffler, S.R.
    CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells (2005), Int. J. Cancer, 116, 243-252.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of wild-type and mutant enzymes in murine BALB/3T3 fibroblasts, and stable expression in CL1-0 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme can associate with tumor-associated antigen L6, TAL6, and enhance the motility of human lung cancer cells and their adhesion to extracellular matrix, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CL1-5 cell highly invasive lung adenocarcinoma cell line, high expression level Homo sapiens
-
HT-1080 cell fibrosarcoma cell line Homo sapiens
-
HUT-125 cell lung adenocarcinoma cell line Homo sapiens
-
lung
-
Homo sapiens
-
lung adenocarcinoma cell
-
Homo sapiens
-
additional information no or poor expression in poorly invasive lung adenocarcinoma CL1-0 cells Homo sapiens
-
PC-3 cell prostate adenocarcinoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-4-nitroanilide + H2O
-
Homo sapiens L-Ala + 4-nitroaniline
-
?
additional information the enzyme can associate with tumor-associated antigen L6, TAL6, and enhance the motility of human lung cancer cells and their adhesion to extracellular matrix, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
Homo sapiens
CD13
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
in vivo assay at Homo sapiens