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Literature summary for 3.4.11.2 extracted from

  • Shim, J.S.; Lee, H.S.; Shin, J.; Kwon, H.J.
    Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro (2004), Cancer Lett., 203, 163-169.
    View publication on PubMed
Search for more literature for 3.4.11.2

Inhibitors

Inhibitors Comment Organism Structure
(2E,2'E)-N,N'-[disulfanediyldi(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamide] PsA, isolated from a marine sponge, inhibits the enzyme non-competitively and suppresses angiogenesis in vitro, IC50 is 0.018 mM Sus scrofa
bestatin transition state analogue of Phe-Leu, competitive Sus scrofa
additional information no inhibition by psammaplin A analogues psammaplin B, psammaplin C, psammaplin A-1, psammaplin C-1, and psammplin D Sus scrofa
psammaplin A
-
 Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-metallopeptidase Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa the enzyme plays a key role in tumor cell invasion and angiogenesis, enzyme inhibition by psammaplin A suppresses the invasion and tube formation of endothelial cells stimulated by basic fibroblast growth factor, and proliferation of cancer and endothelial cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-7-amido-4-methylcoumarin + H2O
-
 Sus scrofa L-Ala + 7-amino-4-methylcoumarin
-
 ?
additional information the enzyme plays a key role in tumor cell invasion and angiogenesis, enzyme inhibition by psammaplin A suppresses the invasion and tube formation of endothelial cells stimulated by basic fibroblast growth factor, and proliferation of cancer and endothelial cells, overview Sus scrofa ?
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
 Sus scrofa
APN
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.015
-
 psammaplin A pH 7.4, 37°C Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.018
-
 PsA, isolated from a marine sponge, inhibits the enzyme non-competitively and suppresses angiogenesis in vitro, IC50 is 0.018 mM Sus scrofa (2E,2'E)-N,N'-[disulfanediyldi(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamide]