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Literature summary for 3.4.11.2 extracted from

  • Noble, F.; Luciani, N.; Da Nacimento, S.; Lai-Kuen, R.; Bischoff, L.; Chen, H.; Fournie-Zaluski, M.C.; Roques, B.P.
    Binding propeties of a highly potent and selecive iodinated aminopeptidase N inhibitor appropriate for radioautography (2000), FEBS Lett., 467, 81-86.
    View publication on PubMed
Search for more literature for 3.4.11.2

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant E350D in COS-7 cells Sus scrofa

Protein Variants

Protein Variants Comment Organism
E350D site-directed double strand mutagenesis, no binding of the inhibitor 2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-iodotyrosine Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
(3-Hydroxycarbamoyl-2-phenyl-propionylamino)-phenyl-acetic acid
-
 Rattus norvegicus
2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-iodotyrosine [125I]-isotope, i.e. [125I]RB 129, highly potent and selective inhibitor, radiolabeled, study of binding properties and kinetics Rattus norvegicus
2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-iodotyrosine [125I]-isotope, i.e. [125I]RB 129, highly potent and selective inhibitor, radiolabeled, study of binding properties and kinetics Sus scrofa
2-amino-4-methylsulfanyl-butane-1-thiol
-
 Rattus norvegicus
additional information competition study of inhibitors Rattus norvegicus
[3-[(1-amino-ethyl)-hydroxy-phosphinoyl]-2-phenyl-propionylamino]-phenyl-acetic acid
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
membrane
-
 Sus scrofa 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metallopeptidase Rattus norvegicus
Zn2+ zinc metallopeptidase Sus scrofa

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebellum
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
 Rattus norvegicus
aminopeptidase N
-
 Sus scrofa
EC 3.4.1.2 formerly Rattus norvegicus
EC 3.4.1.2 formerly Sus scrofa
More the enzyme belongs to peptidase family M1 Rattus norvegicus
More the enzyme belongs to peptidase family M1 Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000077
-
 2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-iodotyrosine recombinant wild-type enzyme, pH 7.4, 35°C Sus scrofa
0.000203
-
 2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-iodotyrosine pH 7.4, 35°C Rattus norvegicus