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Literature summary for 3.4.11.2 extracted from

  • McClellan, J.B.; Garner, C.W.
    Purification and properties of human intestine alanine aminopeptidase (1980), Biochim. Biophys. Acta, 613, 160-167.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 99% inhibition at 0.4 mM, Ki: 0.067 mM Homo sapiens
2,2'-bipyridine 90% inhibition at 5 mM Homo sapiens
8-hydroxyquinoline 91% inhibition at 3 mM Homo sapiens
EDTA 14% inhibition at 1 mM Homo sapiens
Methicillin Ki: 4.61 mM Homo sapiens
phenylalanine Ki: 0.67 mM Homo sapiens
puromycin Ki: 0.0125 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
L-Met-2-naphthylamide
-
Homo sapiens
0.025
-
Lys-2-naphthylamide
-
Homo sapiens
0.067
-
Leu-2-naphthylamide
-
Homo sapiens
0.07
-
L-Val-2-naphthylamide
-
Homo sapiens
0.088
-
L-Arg-2-naphthylamide
-
Homo sapiens
0.091
-
Ala-2-naphthylamide
-
Homo sapiens
0.092
-
L-Ile-2-naphthylamide
-
Homo sapiens
0.108
-
Ser-2-naphthylamide
-
Homo sapiens
0.202
-
Phe-2-naphthylamide
-
Homo sapiens
0.367
-
L-His-2-naphthylamide
-
Homo sapiens
0.617
-
L-Thr-2-naphthylamide
-
Homo sapiens
0.647
-
Leu-p-nitroanilide
-
Homo sapiens
0.74
-
Gly-4-nitroanilide
-
Homo sapiens
0.785
-
L-Asn-2-naphthylamide
-
Homo sapiens
2.33
-
L-Glu-2-naphthylamide
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane mucosal membrane Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ increase of activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
108000
-
2 * 108000, SDS-PAGE Homo sapiens
206000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aminoacyl peptide Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-2-naphthylamide + H2O
-
Homo sapiens Ala + 2-naphthylamine
-
?
aminoacyl peptide
-
Homo sapiens ?
-
?
aminoacyl-2-naphthylamide + H2O preference for substrates having hydrophobic or basic amino terminal residues with no beta-branching Homo sapiens amino acid + 2-naphthylamine
-
?
aminoacyl-p-nitroanilide + H2O
-
Homo sapiens amino acid + nitroaniline
-
?
Gly-4-nitroanilide + H2O
-
Homo sapiens Gly + 4-nitroaniline
-
?
L-Arg-2-naphthylamide + H2O
-
Homo sapiens L-Arg + 2-naphthylamine
-
?
L-Asn-2-naphthylamide + H2O
-
Homo sapiens L-Asn + 2-naphthylamine
-
?
L-Glu-2-naphthylamide + H2O
-
Homo sapiens L-Glu + 2-naphthylamine
-
?
L-His-2-naphthylamide + H2O
-
Homo sapiens L-His + 2-naphthylamine
-
?
L-Ile-2-naphthylamide + H2O
-
Homo sapiens L-Ile + 2-naphthylamine
-
?
L-Lys-2-naphthylamide + H2O
-
Homo sapiens L-Lys + 2-naphthylamine
-
?
L-Met-2-naphthylamide + H2O
-
Homo sapiens L-Met + 2-naphthylamine
-
?
L-Phe-2-naphthylamide + H2O
-
Homo sapiens L-Phe + 2-naphthylamine
-
?
L-Thr-2-naphthylamide + H2O
-
Homo sapiens L-Thr + 2-naphthylamine
-
?
L-Val-2-naphthylamide + H2O
-
Homo sapiens L-Val + 2-naphthylamine
-
?
Leu-2-naphthylamide + H2O
-
Homo sapiens Leu + 2-naphthylamine
-
?
Ser-beta-naphthylamide + H2O
-
Homo sapiens Ser + beta-naphthylamine
-
?

Subunits

Subunits Comment Organism
dimer 2 * 108000, SDS-PAGE Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0125
-
puromycin
-
Homo sapiens
0.067
-
1,10-phenanthroline
-
Homo sapiens
0.67
-
phenylalanine
-
Homo sapiens
4.61
-
Methicillin
-
Homo sapiens