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Literature summary for 3.4.11.2 extracted from
- Microvillus membrane peptidases that catalyze hydrolysis of cysteinylglycine and its derivatives (1985), Methods Enzymol., 113, 471-484.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Rattus norvegicus |  |
| bestatin | - |
Rattus norvegicus | |
| dithiothreitol | no significant inhibition by thiol compounds | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | brush border membrane | Rattus norvegicus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | 2 mol Zn per mol enzyme | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aminoacyl peptide | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | - |
Rattus norvegicus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-Gly | - |
Rattus norvegicus | Ala + Gly | - |
? | |
| Ala-Gly + H2O | - |
Rattus norvegicus | Ala + Gly | - |
? | |
| aminoacyl peptide | - |
Rattus norvegicus | ? | - |
? | |
| aminoacyl peptide + H2O | not glutathione | Rattus norvegicus | alanyl peptides + H2O | - |
? | |
| aminoacyl-p-nitroanilide + H2O | - |
Rattus norvegicus | amino acid + nitroaniline | - |
? | |
| dipeptides + H2O | not: D-Ala-Gly, Val-Gly, Asp-Gly, Gly-D-Ala, Pro-containing peptides | Rattus norvegicus | amino acids | - |
? | |
| tripeptides + H2O | - |
Rattus norvegicus | dipeptides + amino acids | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | substrate Ala-Gly | Rattus norvegicus |
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Release 2023.1 (January 2023)
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