Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.11.2 extracted from

  • Luciani, N.; Marie-Claire, C.; Ruffet, E.; Beaumont, A.; Roques, B.P.; Fournie-Zaluski, M.C.
    Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC 3.4.11.2): insights into its mechanism of action (1998), Biochemistry, 37, 686-692.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Sus scrofa

Protein Variants

Protein Variants Comment Organism
E350A inactive Sus scrofa
E350D reduced activity Sus scrofa
E350Q reduced activity Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Homo sapiens
1,10-phenanthroline
-
Sus scrofa
bestatin
-
Homo sapiens
bestatin
-
Sus scrofa
hydroxamate RB 38A
-
Sus scrofa
phosphinopeptides
-
Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Homo sapiens
Zn2+
-
Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aminoacyl peptide Homo sapiens
-
?
-
?
aminoacyl peptide Sus scrofa
-
?
-
?
enkephalin Sus scrofa
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-p-nitroanilide + H2O
-
Sus scrofa Ala + p-nitroaniline
-
?
aminoacyl peptide
-
Homo sapiens ?
-
?
aminoacyl peptide
-
Sus scrofa ?
-
?
enkephalin
-
Sus scrofa ?
-
?
Leu5-enkephalin + H2O
-
Sus scrofa tyrosin + (2-5)Leu5-enkephalin
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
33.2
-
Leu5-enkephalin
-
Sus scrofa