Literature summary for 3.4.11.18 extracted from

Kawai, M.; BaMaung, N.Y.; Fidanze, S.D.; Erickson, S.A.; Tedrow, J.S.; Sanders, W.J.; Vasudevan, A.; Park, C.; Hutchins, C.; Comess, K.M.; Kalvin, D.; Wang, J.; Zhang, Q.; Lou, P.; Tucker-Garcia, L.; Bouska, J.; Bell, R.L.; Lesniewski, R.; Henkin, J.; Sheppard, G.S.
Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties (2006), Bioorg. Med. Chem. Lett., 16, 3574-3577.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(8S)-2-[[(4-fluorophenyl)sulfonyl]amino]-8-methyl-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid	-	Homo sapiens
2-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-5-bromobenzoic acid	-	Homo sapiens
2-[(phenylsulfonyl)amino]-5-propylbenzoic acid	-	Homo sapiens
2-[[(4-chlorophenyl)sulfonyl]amino]-5-methylbenzoic acid	-	Homo sapiens
2-[[(4-fluorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid	-	Homo sapiens
2-[[(4-fluorophenyl)sulfonyl]amino]-8-methyl-5,6-dihydronaphthalene-1-carboxylic acid	-	Homo sapiens
3,5-dimethyl-2-[(phenylsulfonyl)amino]benzoic acid	-	Homo sapiens
3-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid	-	Homo sapiens
3-[(phenylsulfonyl)amino]naphthalene-2-carboxylic acid	-	Homo sapiens
3-[[(4-fluorophenyl)sulfonyl]amino]naphthalene-2-carboxylic acid	-	Homo sapiens
5-bromo-2-[[(4-chlorophenyl)sulfonyl]amino]benzoic acid	-	Homo sapiens
5-butyl-2-[(phenylsulfonyl)amino]benzoic acid	-	Homo sapiens
5-ethyl-2-[(phenylsulfonyl)amino]benzoic acid	-	Homo sapiens
5-methyl-2-[(phenylsulfonyl)amino]benzoic acid	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Met-peptide + H2O	Homo sapiens	-	Met + peptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50579	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Met-peptide + H2O	-	Homo sapiens	Met + peptide	-	?

Synonyms

Synonyms	Comment	Organism
MetAP-2	-	Homo sapiens
methionine aminopeptidase type II	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000009	-	-	Homo sapiens	3-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid
0.00001	-	-	Homo sapiens	2-[[(4-fluorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
0.000015	-	-	Homo sapiens	3-[[(4-fluorophenyl)sulfonyl]amino]naphthalene-2-carboxylic acid
0.000019	-	-	Homo sapiens	3-[(phenylsulfonyl)amino]naphthalene-2-carboxylic acid
0.00002	-	-	Homo sapiens	2-[[(4-fluorophenyl)sulfonyl]amino]-8-methyl-5,6-dihydronaphthalene-1-carboxylic acid
0.000027	-	-	Homo sapiens	(8S)-2-[[(4-fluorophenyl)sulfonyl]amino]-8-methyl-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
0.00009	-	-	Homo sapiens	5-ethyl-2-[(phenylsulfonyl)amino]benzoic acid
0.00035	-	-	Homo sapiens	3,5-dimethyl-2-[(phenylsulfonyl)amino]benzoic acid
0.001	-	-	Homo sapiens	5-methyl-2-[(phenylsulfonyl)amino]benzoic acid
0.0011	-	-	Homo sapiens	2-[(phenylsulfonyl)amino]-5-propylbenzoic acid
0.0039	-	-	Homo sapiens	2-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-5-bromobenzoic acid
0.0091	-	-	Homo sapiens	5-bromo-2-[[(4-chlorophenyl)sulfonyl]amino]benzoic acid
0.01	-	-	Homo sapiens	5-butyl-2-[(phenylsulfonyl)amino]benzoic acid
0.011	-	-	Homo sapiens	2-[[(4-chlorophenyl)sulfonyl]amino]-5-methylbenzoic acid

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Release 2023.1 (January 2023)