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Literature summary for 3.4.11.18 extracted from

  • Liu, S.; Widom, J.; Kemp, C.W.; Crews, C.M.; Clardy, J.
    Structure of human methionine aminopeptidase-2 complexed with fumagillin (1998), Science, 282, 1324-1327.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
1.8 resolution crystal structure of free enzyme and enzyme complexed with fumagillin. Crystals are grown in 1 to 2 weeks at 4°C from sitting drops, with a protein concentration of 12 mg/ml Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
fumagillin a covalent bond is formed between a reactive epoxide of fumagillin and histidine-231 in the active site of Met-AP2. Fumagillin-based drugs inhibit MetAP-2 but not MetAP-1 Homo sapiens
TNP-470 is likely to inhibit the enzyme by occupying the active site in the same fashion as fumagillin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P50579
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