Crystallization (Comment) | Organism |
---|---|
1.8 resolution crystal structure of free enzyme and enzyme complexed with fumagillin. Crystals are grown in 1 to 2 weeks at 4°C from sitting drops, with a protein concentration of 12 mg/ml | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fumagillin | a covalent bond is formed between a reactive epoxide of fumagillin and histidine-231 in the active site of Met-AP2. Fumagillin-based drugs inhibit MetAP-2 but not MetAP-1 | Homo sapiens | |
TNP-470 | is likely to inhibit the enzyme by occupying the active site in the same fashion as fumagillin | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50579 | - |
- |