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Literature summary for 3.4.11.17 extracted from

  • Kremer, A.; Li, S.M.
    Tryptophan aminopeptidase activity of several indole prenyltransferases from Aspergillus fumigatus (2008), Chem. Biol., 15, 729-738.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ATP 7-DMATS, FgaPT1, CdpNPT, and FtmPT1 show 151.6%, 145%, 243.6%, and 149.4% relative activity at 5 mM ATP, respectively Aspergillus fumigatus

Cloned(Commentary)

Cloned (Comment) Organism
-
Aspergillus fumigatus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ CdpNPT shows 69.2% relative activity at 5 mM Ca2+ Aspergillus fumigatus
Co2+ 7-DMATS, FgaPT1, and CdpNPT show 10.2%, 32.3%, and 46.9% relative activity at 5 mM Co2+, respectively Aspergillus fumigatus
EDTA CdpNPT and FtmPT1 are completely inhibited by 5 mM EDTA, 7-DMATS and FgaPT1 show 11.6% and 43.1% relative activity at 5 mM EDTA Aspergillus fumigatus
Fe2+ CdpNPT and FtmPT1 show 34.2% and 42.8% relative activity at 5 mM Fe2+, 7-DMATS and FgaPT1 are completely inhibited by 5 mM Fe2+ Aspergillus fumigatus
K+ FtmPT1 shows 86.5% relative activity at 5 mM K+ Aspergillus fumigatus
Mn2+ 7-DMATS shows 84.0% relative activity at 5 mM Mn2+, FgaPT1 shows 69.7% relative activity at 5 mM Mn2+ Aspergillus fumigatus
Zn2+ 7-DMATS, FgaPT1, CdpNPT, and FtmPT1 are completely inhibited by 5 mM Zn2+ Aspergillus fumigatus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ FgaPT1 shows 144.2% relative activity at 5 mM Ca2+, FtmPT1 shows 144.1% relative activity at 5 mM Ca2+ Aspergillus fumigatus
Co2+ FtmPT1 shows 130.4% relative activity at 5 mM Co2+ Aspergillus fumigatus
K+ FgaPT1 shows 117.9% relative activity at 5 mM Co2+ Aspergillus fumigatus
Mg2+ FgaPT1 shows 137.9% relative activity at 5 mM Mg2+, FtmPT1 shows 155.2% relative activity at 5 mM Mg2+ Aspergillus fumigatus
Mn2+ CdpNPT shows 591.2% relative activity at 5 mM Mn2+, FtmPT1 shows 421.6% relative activity at 5 mM Mn2+ Aspergillus fumigatus
additional information 7-DMATS is not activated by 5 mM Ca2+, K+, or Mg2+. CdpNPT is not activated by 5 mM Mg2+ or K+. 7-DMATS, FgaPT1, CdpNPT, and FtmPT1 are not influenced by Na+ Aspergillus fumigatus

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Aspergillus fumigatus

Synonyms

Synonyms Comment Organism
7-DMATS the indole prenyltransferase functions also as tryptophan aminopeptidases and accepts linear dipeptides as best substrates Aspergillus fumigatus
CdpNPT the indole prenyltransferase functions also as tryptophan aminopeptidases and accepts linear dipeptides as best substrates Aspergillus fumigatus
FgaPT1 the indole prenyltransferase functions also as tryptophan aminopeptidases and accepts linear dipeptides as best substrates Aspergillus fumigatus
FtmPT1 the indole prenyltransferase functions also as tryptophan aminopeptidases and accepts linear dipeptides as best substrates Aspergillus fumigatus