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Literature summary for 3.4.11.16 extracted from

  • Hooper, N.M.
    X-Trp aminopeptidase (2004), Handbook of Proteolytic Enzymes (Barrett, A.J., Rawlings, N.D., Woessner, J.F., eds), 2nd. ed., 1013-1014.
No PubMed abstract available
Search for more literature for 3.4.11.16

Inhibitors

Inhibitors Comment Organism Structure
amastatin
-
 Sus scrofa
bestatin
-
 Sus scrofa
phosphate
-
 Sus scrofa
probestin
-
 Sus scrofa
rentiapril the enzyme has an overlapping substrate specificity and inhibitor profile with the related mammalian membrane-bound zinc aminopeptidases membrane alanyl aminopeptidase (EC 3.4.11.2) and glutamyl aminopeptidase (EC 3.4.11.16), but can be distinguished from them by its inhibition by rentiopril and zofenoprilat Sus scrofa
zofenoprilat the enzyme has an overlapping substrate specificity and inhibitor profile with the related mammalian membrane-bound zinc aminopeptidases membrane alanyl aminopeptidase (EC 3.4.11.2) and glutamyl aminopeptidase (EC 3.4.11.16), but can be distinguished from them by its inhibition by rentiopril and zofenoprilat Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral membrane protein, microvillar membrane Sus scrofa 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn the enzyme contains 1.2 atoms of zinc per subunit Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
130000
-
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa may be involved in neuropeptide metabolism, may play a minor role in the intestinal metabolism of the artificial sweetener aspartame ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Sus scrofa

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Sus scrofa
-
kidney proximal tubule Sus scrofa
-
neuron myelinated and unmyelinated neurons of the peripheral nervous system Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Asp-Phe-NH2 + H2O
-
 Sus scrofa Asp + Phe-NH2
-
 ?
Glu-Trp + H2O
-
 Sus scrofa Glu + Trp
-
 ?
additional information may be involved in neuropeptide metabolism, may play a minor role in the intestinal metabolism of the artificial sweetener aspartame Sus scrofa ?
-
 ?
additional information the enzyme cleaves Leu-/-Trp, it prefers short peptides with an aromatic residue in the P1' position, with Glu-/-Trp being the best substrate. Dipeptides with Trp, Phe or Tr in the P1' position are rapidly hydrolyzed. The requirement in the P1 position is no stringent. Te enzyme does not hydrolyze N-blocked peptides Sus scrofa ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Sus scrofa