Application | Comment | Organism |
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medicine | coexpression of Drosophila puromycin-sensitive aminopeptidase and beta-amyloid in the flies' brains improves their lifespan, protects against locomotor deficits, and reduces brain beta-amyloid levels by clearing the beta-amyloid plaque-like deposits. Puromycin-sensitive aminopeptidase localizes to the cytoplasm. Therefore, puromycin-sensitive aminopeptidase and beta-amyloid are unlikely to be in the same cellular compartment. Beta-amyloid is not a proteolytic substrate for puromycin-sensitive aminopeptidase in vitro. The enzymatic activity of puromycin-sensitive aminopeptidase is not required for rescuing beta-amyloid toxicity in neuronal SH-SY5Y cells | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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cytoplasm | - |
Drosophila melanogaster | 5737 | - |
Organism | UniProt | Comment | Textmining |
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Drosophila melanogaster | - |
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