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Literature summary for 3.4.11.14 extracted from

  • Kudo, L.C.; Parfenova, L.; Ren, G.; Vi, N.; Hui, M.; Ma, Z.; Lau, K.; Gray, M.; Bardag-Gorce, F.; Wiedau-Pazos, M.; Hui, K.S.; Karsten, S.L.
    Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice (2011), Hum. Mol. Genet., 20, 1820-1833.
    View publication on PubMed
Search for more literature for 3.4.11.14

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ion exchange chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Leu-(beta-naphthylamine) + H2O
-
 Homo sapiens Leu + naphthylamine
-
 ?
Leu-4-methyl-coumaryl-7-amide + H2O
-
 Homo sapiens Leu + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
PSA/NPEPPS
-
 Homo sapiens
puromycin-sensitive aminopeptidase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function elevation of activity in vivo effectively blocks accumulation of soluble hyperphosphorylated TAU protein and slows down the progression of neurodegeneration in the mammalian system Homo sapiens