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Literature summary for 3.4.11.14 extracted from
- Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration (2007), Neurochem. Res., 32, 2062-2071.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amastatin | - |
Mus musculus |  |
| amastatin | - |
Rattus norvegicus | |
| puromycin | - |
Mus musculus | |
| puromycin | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00095 | - |
Met-enkephalin | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | 80% of the PSA resides in the cytosol | Mus musculus | 5829 | - |
| membrane | 20% of the PSA is associated with the membrane | Mus musculus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | Mg2+ restores the activity of the apoenzyme | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Rattus norvegicus | - |
| cerebral cortex | - |
Mus musculus | - |
| hippocampus | - |
Mus musculus | - |
| hippocampus | - |
Rattus norvegicus | - |
| hypothalamus | - |
Mus musculus | - |
| thalamus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Arg-enkephalin + H2O | - |
Mus musculus | L-Arg + enkephalin | - |
? | |
| Met-enkephalin + H2O | - |
Rattus norvegicus | ? | releases only the N-terminal tyrosine | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 110000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GenePSA-dependent puromycin-sensitive aminopeptidase | - |
Mus musculus |
| NAP | - |
Mus musculus |
| NAP | - |
Rattus norvegicus |
| NPEPPS | - |
Mus musculus |
| PSA | - |
Mus musculus |
| puromycin-sensitive aminopeptidase | - |
Mus musculus |
| puromycin-sensitive neuron-aminopeptidase | - |
Mus musculus |
| puromycin-sensitive neuron-aminopeptidase | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00004 | - |
amastatin | - |
Rattus norvegicus | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Rattus norvegicus | isoelectric focusing | - |
5.25 |
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Release 2023.1 (January 2023)
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