General Stability | Organism |
---|---|
when the enzyme is treated at 60°C with EDTA the inhibition is no longer reversible and there is a concomitant loss of zinc | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | 99% inhibition at 0.5 mM; Ki 0.028 mM | Homo sapiens | |
2,2'-bipyridine | 5.0 mM, 29% inhibition | Homo sapiens | |
2,9-Dimethyl-1,10-phenanthroline | 2.0 mM, 52% inhibition | Homo sapiens | |
8-hydroxyquinoline | 2.0 mM, 84% inhibition | Homo sapiens | |
azide | 92% inhibition at 10 mM | Homo sapiens | |
cyanide | 84% inhibition at 10 mM | Homo sapiens | |
EDTA | 98% inhibition at 0.001 mM | Homo sapiens | |
EGTA | 96% inhibition at 1 mM; Ki 0.012 mM | Homo sapiens | |
KCN | 10 mM, 84% inhibition | Homo sapiens | |
Na2S | 10 mM, 92% inhibition | Homo sapiens | |
oxalate | 50 mM ammonium oxalate, 71% inhibition | Homo sapiens | |
Sulfide | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | Km: 0.05 mM | Homo sapiens | |
Co2+ | 2.4fold activation, Co2+ binds loosely in a noncompetitive manner | Homo sapiens | |
Zinc | 8.3 nanoatoms of tightly bound zinc per mg of protein | Homo sapiens | |
Zinc | zinc is located near the substrate binding site | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
EGTA | - |
Homo sapiens | |
0.028 | - |
1,10-phenanthroline | - |
Homo sapiens | |
0.076 | - |
Sulfide | - |
Homo sapiens |