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Literature summary for 3.4.11.14 extracted from
- Hydrophobic binding sites of human liver alanine aminopeptidase (1977), Arch. Biochem. Biophys., 182, 667-673.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 11-aminoundecanoic acid | - |
Homo sapiens |  |
| 6-aminohexanoic acid | - |
Homo sapiens | |
| acetonitrile | 20% complete loss of activity | Homo sapiens | |
| Dimethyl formamide | - |
Homo sapiens | |
| dodecanedioic acid | - |
Homo sapiens | |
| dodecanoic acid | - |
Homo sapiens | |
| ethanol | inactivation above 30% | Homo sapiens | |
| hexanedioic acid | - |
Homo sapiens | |
| hexanoic acid | - |
Homo sapiens | |
| methanol | inactivation only above 30% | Homo sapiens | |
| Methyl cellosolve | 40% loss of activity at 40% solvent | Homo sapiens | |
| NaCl | hydrolysis of Ala-4-nitropanilide, competitive inhibition at pH 6.6, inhibition is noncompetitive at pH 5.8, inhibition is mixed type at pH 6.2 | Homo sapiens | |
| p-dioxane | inactivation only above 30% | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-2-naphthylamide + H2O | - |
Homo sapiens | Ala + 2-naphthylamine | - |
? | |
| Ala-4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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