Literature summary for 3.4.11.10 extracted from

Prescott, J.M.; Wagner, F.W.; Holmquist, B.; Vallee, B.L.
One hundred fold increased activity of Aeromonas aminopeptidase by sequential substitutions with Ni(II) or Cu(II) followed by zinc (1983), Biochem. Biophys. Res. Commun., 114, 646-652.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	-	Vibrio proteolyticus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Co2+	if copper or cobalt are added prior to zinc in sequential substitution experiments, activation is two orders of magnitude higher than the other way round, which suggests two metal-binding sites with different functions	Vibrio proteolyticus
Cu2+	if copper or cobalt are added prior to zinc in sequential substitution experiments, activation is two orders of magnitude higher than the other way round, which suggests two metal-binding sites with different functions	Vibrio proteolyticus
Ni2+	-	Vibrio proteolyticus
Zn2+	if copper or cobalt are added prior to zinc in sequential substitution experiments, activation is two orders of magnitude higher than in the opposite sequence, which suggests two metal-binding sites with different functions	Vibrio proteolyticus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Peptides + H2O	Vibrio proteolyticus	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Vibrio proteolyticus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Peptides + H2O	-	Vibrio proteolyticus	?	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Vibrio proteolyticus

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Release 2023.1 (January 2023)