Literature summary for 3.4.11.10 extracted from

Hanaya, K.; Suetsugu, M.; Saijo, S.; Yamato, I.; Aoki, S.
Potent inhibition of dinuclear zinc(II) peptidase, an aminopeptidase from Aeromonas proteolytica, by 8-quinolinol derivatives: inhibitor design based on Zn2+ fluorophores, kinetic, and X-ray crystallographic study (2012), J. Biol. Inorg. Chem., 17, 517-529.

Search for more literature for 3.4.11.10

Inhibitors

Inhibitors	Comment	Organism
2-methylquinolin-8-ol	-	Vibrio proteolyticus
3-methylquinolin-8-ol	-	Vibrio proteolyticus
5,7-dibromoquinolin-8-ol	-	Vibrio proteolyticus
5,7-dichloroquinolin-8-ol	-	Vibrio proteolyticus
5,7-diiodoquinolin-8-ol	-	Vibrio proteolyticus
5-(trifluoromethyl)quinolin-8-ol	-	Vibrio proteolyticus
5-bromo-2-methylquinolin-8-ol	-	Vibrio proteolyticus
5-bromo-8-hydroxy-2-methylquinoline-7-sulfonamide	-	Vibrio proteolyticus
5-bromo-8-hydroxy-N,2-dimethylquinoline-7-sulfonamide	-	Vibrio proteolyticus
5-bromo-8-hydroxy-N,N,2-trimethylquinoline-7-sulfonamide	-	Vibrio proteolyticus
5-bromoquinolin-8-ol	-	Vibrio proteolyticus
5-chloro-2-methylquinolin-8-ol	-	Vibrio proteolyticus
5-chloro-7-iodoquinolin-8-ol	-	Vibrio proteolyticus
5-chloro-8-hydroxy-N,N-dimethylquinoline-7-sulfonamide	-	Vibrio proteolyticus
5-chloro-8-hydroxy-N-methylquinoline-7-sulfonamide	-	Vibrio proteolyticus
5-chloro-8-hydroxyquinoline-7-sulfonamide	-	Vibrio proteolyticus
5-chloroquinolin-8-ol	-	Vibrio proteolyticus
5-fluoroquinolin-8-ol	-	Vibrio proteolyticus
5-iodoquinolin-8-ol	-	Vibrio proteolyticus
5-nitroquinolin-8-ol	-	Vibrio proteolyticus
8-hydroxy-N,N-dimethylquinoline-5-sulfonamide	-	Vibrio proteolyticus
quinolin-8-ol	-	Vibrio proteolyticus

Organism

Organism	UniProt	Comment	Textmining
Vibrio proteolyticus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Leu-4-nitroanilide + H2O	-	Vibrio proteolyticus	L-Leu + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
AAP	-	Vibrio proteolyticus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Vibrio proteolyticus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Vibrio proteolyticus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.000062	-	5-iodoquinolin-8-ol	pH 8, 25°C	Vibrio proteolyticus
0.00019	-	5-chloro-8-hydroxyquinoline-7-sulfonamide	pH 8, 25°C	Vibrio proteolyticus
0.00037	-	5-(trifluoromethyl)quinolin-8-ol	pH 8, 25°C	Vibrio proteolyticus
0.00046	-	3-methylquinolin-8-ol	pH 8, 25°C	Vibrio proteolyticus
0.00058	-	quinolin-8-ol	pH 8, 25°C	Vibrio proteolyticus
0.00068	-	5-fluoroquinolin-8-ol	pH 8, 25°C	Vibrio proteolyticus
0.00081	-	5-chloro-8-hydroxy-N-methylquinoline-7-sulfonamide	pH 8, 25°C	Vibrio proteolyticus
0.011	-	5-chloroquinolin-8-ol	pH 8, 25°C	Vibrio proteolyticus
0.016	-	5-bromoquinolin-8-ol	pH 8, 25°C	Vibrio proteolyticus
0.029	-	5-nitroquinolin-8-ol	pH 8, 25°C	Vibrio proteolyticus
0.1	-	2-methylquinolin-8-ol	value above, pH 8, 25°C	Vibrio proteolyticus
0.1	-	5-chloro-8-hydroxy-N,N-dimethylquinoline-7-sulfonamide	value above, pH 8, 25°C	Vibrio proteolyticus
0.1	-	5,7-dichloroquinolin-8-ol	value above, pH 8, 25°C	Vibrio proteolyticus
0.1	-	5,7-dibromoquinolin-8-ol	value above, pH 8, 25°C	Vibrio proteolyticus
0.1	-	5,7-diiodoquinolin-8-ol	value above, pH 8, 25°C	Vibrio proteolyticus
0.1	-	5-chloro-7-iodoquinolin-8-ol	value above, pH 8, 25°C	Vibrio proteolyticus
0.1	-	8-hydroxy-N,N-dimethylquinoline-5-sulfonamide	value above, pH 8, 25°C	Vibrio proteolyticus
0.1	-	5-chloro-2-methylquinolin-8-ol	value above, pH 8, 25°C	Vibrio proteolyticus
0.1	-	5-bromo-2-methylquinolin-8-ol	value above, pH 8, 25°C	Vibrio proteolyticus
0.1	-	5-bromo-8-hydroxy-2-methylquinoline-7-sulfonamide	value above, pH 8, 25°C	Vibrio proteolyticus
0.1	-	5-bromo-8-hydroxy-N,2-dimethylquinoline-7-sulfonamide	value above, pH 8, 25°C	Vibrio proteolyticus
0.1	-	5-bromo-8-hydroxy-N,N,2-trimethylquinoline-7-sulfonamide	value above, pH 8, 25°C	Vibrio proteolyticus