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Literature summary for 3.4.11.10 extracted from
- Leucine aminopeptidase (2004), Handbook of Metalloproteins (Messerschmidt, A. ; Huber, R. ; Wieghardt, K. ; Palos, T. , eds. ), 3, 199-207.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bicarbonate | activates | Escherichia coli |  |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystallization at pH 8.0 of enzyme in high salt Tris buffer against low salt concentration, X-ray diffraction crystal structure determination and analysis at 2.5 A resolution | Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | metallopeptidase, dimetal site structure, overview | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Escherichia coli | PepA acts as DNA-binding protein in Xer site-specific DNA recombination serving as accessory protein | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. | catalytic mechanism | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Leu-4-nitroanilide + H2O | - |
Escherichia coli | L-Leu + 4-nitroaniline | - |
? | |
| additional information | PepA acts as DNA-binding protein in Xer site-specific DNA recombination serving as accessory protein | Escherichia coli | ? | - |
? | |
| additional information | PepA binds DNA probably along the large groove that runs from the lower trimer face across the twofold molecular axis to the upper trimer face | Escherichia coli | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | lens enzyme three-dimensional structure and protein fold, overview | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LAP | - |
Escherichia coli |
| leucine aminopeptidase | - |
Escherichia coli |
| More | the enzyme belongs to the peptidase family M17 | Escherichia coli |
| PepA | - |
Escherichia coli |
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