Crystallization (Comment) | Organism |
---|---|
analysis of crystal structures of free Zn-enzyme, and Zn-enyme bound to different inhibitors, complex optimizations, overview | Vibrio proteolyticus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-butaneboronic acid | binding mode | Vibrio proteolyticus | |
4-iodo-D-phenylalanine hydroxamate | binding mode | Vibrio proteolyticus | |
L-leucine phosphonic acid | binding mode | Vibrio proteolyticus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | the metallopeptidase requires two divalent metal ions per enzyme molecule for full activity, binuclear metal center activation and reaction mechanism | Vibrio proteolyticus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Vibrio proteolyticus | Q01693 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. | active site structure, reaction mechanism involving divalent metal ions, overview | Vibrio proteolyticus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | investigation of the mode of action using a quantum mechanical/molecular mechanical approach | Vibrio proteolyticus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AAP | - |
Vibrio proteolyticus |