Cloned (Comment) | Organism |
---|---|
a lentivirus is used to induce K-562 cells to overexpress LAP3 (K562-LAP3) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | method development for usage of human leucine aminopeptidase to evaluate the suppression of enzyme activity by an LAP3 inhibitor | Homo sapiens | |
ubenimex | suppresses the enzyme activity in vivo in K562-LAP3 cells, detection method development and evaluation, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | leucine aminopeptidases (LAPs) are zinc-containing metalloproteinases | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28838 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BV-2 cell | - |
Homo sapiens | - |
EAhy 926 cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
PLC/PRF/5 cell | - |
Homo sapiens | - |
RMC cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-leucine 4-nitroanilide + H2O | - |
Homo sapiens | L-leucine + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytosol aminopeptidase | UniProt | Homo sapiens |
lap3 | - |
Homo sapiens |
leucine aminopeptidase 3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | leucine aminopeptidases (LAPs) are members of the aminopeptidase M1/M17 family | Homo sapiens |
physiological function | expression of leucine aminopeptidase 3 (LAP3) is associated with the prognosis for and malignant transformation of many types of tumors | Homo sapiens |