Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amastatin | transition-state analogue | Bos taurus | |
amastatin | transition-state analogue, low toxicity in vivo | Homo sapiens | |
amastatin | transition-state analogue | Sus scrofa | |
bestatin | transition-state analogue | Bos taurus | |
bestatin | transition-state analogue | Homo sapiens | |
bestatin | transition-state analogue | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | kidney enzyme | Sus scrofa | 5829 | - |
additional information | the enzyme is associated with the proteasome | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | metallopeptidase | Homo sapiens | |
Zn2+ | metallopeptidase | Sus scrofa | |
Zn2+ | metallopeptidase | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme has tissue-specifici physiological roles, e.g. trimmíng of the N-terminus of antigenic peptides for presentation or in eye cataract, overview | ? | - |
? | |
additional information | Sus scrofa | the enzyme has tissue-specifici physiological roles, overview | ? | - |
? | |
additional information | Bos taurus | the enzyme has tissue-specifici physiological roles, overview, active site structure and zinc-binding, mechanism | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from kidney to homogeneity | Sus scrofa |
native enzyme from lens to homogeneity | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | purified kidney enzyme | Sus scrofa | - |
eye | - |
Homo sapiens | - |
intestinal mucosa | - |
Sus scrofa | - |
kidney | - |
Sus scrofa | - |
lens | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme has tissue-specifici physiological roles, e.g. trimmíng of the N-terminus of antigenic peptides for presentation or in eye cataract, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme has tissue-specifici physiological roles, overview | Sus scrofa | ? | - |
? | |
additional information | the enzyme has tissue-specifici physiological roles, overview, active site structure and zinc-binding, mechanism | Bos taurus | ? | - |
? | |
additional information | substrate specificity, overview, active site structure | Sus scrofa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LAP | - |
Homo sapiens |
LAP | - |
Sus scrofa |
LAP | - |
Bos taurus |
leucyl aminopeptidase (animal) | - |
Homo sapiens |
leucyl aminopeptidase (animal) | - |
Sus scrofa |
leucyl aminopeptidase (animal) | - |
Bos taurus |
More | the enzyme belongs to the peptidase family M17 | Homo sapiens |
More | the enzyme belongs to the peptidase family M17 | Sus scrofa |
More | the enzyme belongs to the peptidase family M17 | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | 9.5 | kidney enzyme | Sus scrofa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000013 | - |
amastatin | lens enzyme | Bos taurus | |
0.0002 | - |
amastatin | kidney enzyme | Sus scrofa |