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Literature summary for 3.4.11.1 extracted from
- Role of aminopeptidases in the blood pressure regulation (2004), Biol. Pharm. Bull., 27, 768-771.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| genotyping | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K528R | A-LAP polymorphism, leads to hypertension | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | A-LAP ia a zinc-metallopeptidase | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin II + H2O | Homo sapiens | i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | Asp + angiotensin III | i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | ? | |
| additional information | Homo sapiens | A-LAP plays a key role in the MHC class I antigen-presentation pathway, the enzyme is involved in the renin-angiotensin-system, RAS, and angiotensin II metabolism, and plays a role in blood pressure decrease through inactivation of angiotensin II, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | - |
Homo sapiens | - |
| kidney | cortex | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin II + H2O | i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | Homo sapiens | Asp + angiotensin III | i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | ? | |
| kallidin + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | A-LAP plays a key role in the MHC class I antigen-presentation pathway, the enzyme is involved in the renin-angiotensin-system, RAS, and angiotensin II metabolism, and plays a role in blood pressure decrease through inactivation of angiotensin II, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| A-LAP | - |
Homo sapiens |
| leucine aminopeptidase | - |
Homo sapiens |
| More | the enzyme belongs to the M1 peptidase family | Homo sapiens |
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Release 2023.1 (January 2023)
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