Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli JM101 cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
mutant E296Q in complex with N-(4-oxo-4-pyrrolidinyl-butanoyl)-L-proline, liquid/liquid diffusion method, using 22-30% (w/v) PEG 8000, 100 mM NaAc, 100 mM imidazole buffer (pH 6.5-7.0), and 5 mM YbCl3 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E296Q | inactive | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(4-benzylphenyl)thiazol-2-amine | - |
Homo sapiens | |
SC-57461A | i.e. N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-L-alanine | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc metalloenzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | Homo sapiens | - |
leukotriene B4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09960 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Ala-4-nitroanilide + H2O | - |
Homo sapiens | L-Ala + 4-nitroaniline | - |
? | |
L-Pro-Gly-L-Pro + H2O | - |
Homo sapiens | ? | - |
? | |
L-Val-4-nitroanilide + H2O | - |
Homo sapiens | L-Val + 4-nitroaniline | - |
? | |
leukotriene A4 + H2O | - |
Homo sapiens | leukotriene B4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
leukotriene A4 hydrolase | - |
Homo sapiens |
leukotriene A4 hydrolase/aminopeptidase | - |
Homo sapiens |
LTA4H | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0023 | - |
4-(4-benzylphenyl)thiazol-2-amine | at pH 7.8 and 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0005 | - |
at pH 7.8 and 37°C | Homo sapiens | 4-(4-benzylphenyl)thiazol-2-amine |