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Literature summary for 3.3.2.6 extracted from

  • Meng, H.; Liu, Y.; Zhai, Y.; Lai, L.
    Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase (2013), Eur. J. Med. Chem., 59, 160-167.
    View publication on PubMed
Search for more literature for 3.3.2.6

Inhibitors

Inhibitors Comment Organism Structure
2-(5-(2-(4-phenoxyphenoxy)ethoxy)-1H-indol-3-yl)ethanaminium chloride
-
 Homo sapiens
2-(5-(3-phenoxybenzyloxy)-1H-indol-3-yl)ethanaminium chloride
-
 Homo sapiens
2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethanaminium chloride
-
 Homo sapiens
3-(2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethylamino)propanoic acid
-
 Homo sapiens
5-hydroxytryptamine
-
 Homo sapiens
bestatin
-
 Homo sapiens
JMC08-4 i.e. 1,2-amino-3-[5-(benzyloxy)-1H-indol-3-yl] propanoic acid Homo sapiens
methyl 3-(2-(5-(3-phenoxybenzyloxy)-1H-indol-3-yl)ethylamino)propanoate
-
 Homo sapiens
methyl 3-(2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethylamino)propanoate
-
 Homo sapiens
additional information not inhibited by NI101, 2-(5-(benzyloxy)-1H-indol-3-yl)ethanaminium chloride, 2-(5-(naphthalen-2-ylmethoxy)-1H-indol-3-yl)ethanaminiumchloride, 2-(5-(naphthalen-1-ylmethoxy)-1H-indol-3-yl)ethanaminium chloride, 2-(5-(3-phenoxybenzyloxy)-1H-indol-3-yl)ethanaminium chloride, 2-(5-(2-(4-(4-nitrophenoxy)phenoxy)ethoxy)-1H-indol-3-yl)ethanaminium chloride, 2-(5-(2-(4-(2-nitrophenoxy)phenoxy)ethoxy)-1H-indol-3-yl) ethanaminium chloride, 3-(2-(5-(3-phenoxybenzyloxy)-1H-indol-3-yl)ethylamino)propanoic acid, and 3-(2-(5-(2-(4-phenoxyphenoxy)ethoxy)-1H-indol-3-yl) ethylamino)propanoic acid Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains zinc Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
69000
-
 x * 69000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens
-
 leukotriene B4
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?

Subunits

Subunits Comment Organism
? x * 69000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
leukotriene A4 hydrolase
-
 Homo sapiens
LTA4H
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0024
-
 in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens methyl 3-(2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethylamino)propanoate
0.0038
-
 in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 3-(2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethylamino)propanoic acid
0.0042
-
 in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens bestatin
0.0076
-
 in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens methyl 3-(2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethylamino)propanoate
0.015
-
 in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 2-(5-(2-(4-phenoxyphenoxy)ethoxy)-1H-indol-3-yl)ethanaminium chloride
0.0158
-
 in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens methyl 3-(2-(5-(3-phenoxybenzyloxy)-1H-indol-3-yl)ethylamino)propanoate
0.018
-
 in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethanaminium chloride
0.231
-
 in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens JMC08-4