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Literature summary for 3.3.2.6 extracted from

  • Okubo, M.; Yamanaka, H.; Kobayashi, K.; Noguchi, K.
    Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain (2010), Glia, 58, 599-610.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
semiquantitative LTA4H expression analysis in peripheral nerves and spinal cord, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Rattus norvegicus
-
leukotriene B4
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P30349 male Sprague Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
microglia
-
Rattus norvegicus
-
nerve peripheral Rattus norvegicus
-
neuron
-
Rattus norvegicus
-
spinal cord enzyme expression analysis, LTA4h mRNA is expressed in both spinal neurons and microglia, overview Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
Rattus norvegicus leukotriene B4
-
?

Synonyms

Synonyms Comment Organism
LTA4 hydrolase
-
Rattus norvegicus
LTA4H
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction increase of leukotriene synthesis in spinal microglia produced via p38 MAPK plays a role in the generation of neuropathic pain Rattus norvegicus