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Literature summary for 3.3.2.6 extracted from

  • Tobin, D.M.; Vary, J.C.; Ray, J.P.; Walsh, G.S.; Dunstan, S.J.; Bang, N.D.; Hagge, D.A.; Khadge, S.; King, M.C.; Hawn, T.R.; Moens, C.B.; Ramakrishnan, L.
    The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans (2010), Cell, 140, 717-730.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.6

Cloned(Commentary)

Cloned (Comment) Organism
the enzyme is encoded in the lta4h locus, lta4h interacts with the TNF signaling pathway Danio rerio
the enzyme is encoded in the lta4h locus, lta4h interacts with the TNF signaling pathway. LthA4 genotyping in leprosy patients from Vietnam and Nepal, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mutations in the leukotriene A4 hydrolase gene result in decreased lta4h mRNA expression and increased susceptibility to Mycobacterial infection. lta4h mutations confer hypersusceptibility independent of LTB4 reduction, by redirecting eicosanoid substrates to anti-inflammatory lipoxins. The resultant anti-inflammatory state permits increased mycobacterial proliferation by limiting production of tumor necrosis factor. Lta4h deficiencies result in an immunoregulatory phenotype, overview. Two single-nucleotide polymorphisms are rs1978331 and rs2660898, overview Homo sapiens
additional information screening for mutagenized zebrafish larvae phenotypes that differ in their ability to control the replication of Mycobacterium marinum, overview. Three classes of mutants that are hypersusceptible to Mycobacterium marinum infection, one of which mapps to the lta4h locus. The phenotype is not reversible by addition of exogenous LTB4. Induced lta4h deficiency in either wild-type or mutant larvae compromises neither mycobacterially-induced recruitment to the hindbrain ventricle nor bacterial phagocytosis. Lta4h deficiency compromises TNF induction and phenotypically resembles TNF signaling deficiency Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, a potent chemoattractant and proinflammatory eicosanoid leukotriene B4
-
 ?
leukotriene A4 + H2O Danio rerio leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, a potent chemoattractant and proinflammatory eicosanoid. LTB4 functions as a macrophage chemoattractant in the zebrafish, injection into the hindbrain ventricle of wild-type arvae induces rapid recruitment of macrophages leukotriene B4
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 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
 the enzyme is encoded in the lta4h locus
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Homo sapiens
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 the enzyme is encoded in the lta4h locus
-

Source Tissue

Source Tissue Comment Organism Textmining
larva
-
 Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?
leukotriene A4 + H2O
-
 Danio rerio leukotriene B4
-
 ?
leukotriene A4 + H2O leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, a potent chemoattractant and proinflammatory eicosanoid Homo sapiens leukotriene B4
-
 ?
leukotriene A4 + H2O leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, a potent chemoattractant and proinflammatory eicosanoid. LTB4 functions as a macrophage chemoattractant in the zebrafish, injection into the hindbrain ventricle of wild-type arvae induces rapid recruitment of macrophages Danio rerio leukotriene B4
-
 ?

Synonyms

Synonyms Comment Organism
leukotriene A4 hydrolase
-
 Homo sapiens
leukotriene A4 hydrolase
-
 Danio rerio

General Information

General Information Comment Organism
metabolism leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, LTB4, a potent chemoattractant and proinflammatory eicosanoid Homo sapiens
metabolism leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, LTB4, a potent chemoattractant and proinflammatory eicosanoid Danio rerio
additional information protection from both tuberculosis and multibacillary leprosy is associated with heterozygosity for LTA4H polymorphisms Homo sapiens