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Literature summary for 3.3.2.6 extracted from

  • Enache, L.A.; Zhang, J.; Sullins, D.W.; Kennedy, I.; Onua, E.; Zembower, D.E.; Muellner, F.W.; Singh, J.; Kiselyov, A.S.
    Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051 (2009), Bioorg. Med. Chem. Lett., 19, 6275-6279.
    View publication on PubMed
Search for more literature for 3.3.2.6

Inhibitors

Inhibitors Comment Organism Structure
4-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid i.e. DG-051, a phase II clinical candidate Canis lupus familiaris
4-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid i.e. DG-051, a phase II clinical candidate Homo sapiens
4-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid i.e. DG-051, a phase II clinical candidate Rattus norvegicus
4-[(2S)-2-[[4-(4-chloro-2-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid i.e. DG-051 M1-A, a derivative derived from DG-051 Canis lupus familiaris
4-[(2S)-2-[[4-(4-chloro-2-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid i.e. DG-051 M1-A, a derivative derived from DG-051 Homo sapiens
4-[(2S)-2-[[4-(4-chloro-2-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid i.e. DG-051 M1-A, a derivative derived from DG-051 Rattus norvegicus
4-[(2S)-2-[[4-(4-chloro-3-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid i.e. DG-051 M1-B, a derivative derived from DG-051 Canis lupus familiaris
4-[(2S)-2-[[4-(4-chloro-3-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid i.e. DG-051 M1-B, a derivative derived from DG-051 Homo sapiens
4-[(2S)-2-[[4-(4-chloro-3-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid i.e. DG-051 M1-B, a derivative derived from DG-051 Rattus norvegicus
4-[(2S)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-oxidopyrrolidin-1-yl]butanoic acid i.e. DG-051 M2, an N-oxide derivative derived from DG-051 Canis lupus familiaris
4-[(2S)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-oxidopyrrolidin-1-yl]butanoic acid i.e. DG-051 M2, an N-oxide derivative derived from DG-051 Homo sapiens
4-[(2S)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-oxidopyrrolidin-1-yl]butanoic acid i.e. DG-051 M2, an N-oxide derivative derived from DG-051 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Canis lupus familiaris
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ LTA4H is a zinc metalloprotease Homo sapiens
Zn2+ LTA4H is a zinc metalloprotease Rattus norvegicus
Zn2+ LTA4H is a zinc metalloprotease Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens
-
 leukotriene B4
-
 ?
leukotriene A4 + H2O Rattus norvegicus
-
 leukotriene B4
-
 ?
leukotriene A4 + H2O Canis lupus familiaris
-
 leukotriene B4
-
 ?
additional information Homo sapiens LTA4H is a zinc metalloprotease ?
-
 ?
additional information Rattus norvegicus LTA4H is a zinc metalloprotease ?
-
 ?
additional information Canis lupus familiaris LTA4H is a zinc metalloprotease ?
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?
leukotriene A4 + H2O
-
 Rattus norvegicus leukotriene B4
-
 ?
leukotriene A4 + H2O
-
 Canis lupus familiaris leukotriene B4
-
 ?
additional information LTA4H is a zinc metalloprotease Homo sapiens ?
-
 ?
additional information LTA4H is a zinc metalloprotease Rattus norvegicus ?
-
 ?
additional information LTA4H is a zinc metalloprotease Canis lupus familiaris ?
-
 ?

Synonyms

Synonyms Comment Organism
leukotriene A4 hydrolase
-
 Homo sapiens
leukotriene A4 hydrolase
-
 Rattus norvegicus
leukotriene A4 hydrolase
-
 Canis lupus familiaris
LTA4H
-
 Homo sapiens
LTA4H
-
 Rattus norvegicus
LTA4H
-
 Canis lupus familiaris

General Information

General Information Comment Organism
metabolism LTA4H catalyzes the last step in the synthesis of the pro-inflammatory molecule leukotriene B4 Homo sapiens
metabolism LTA4H catalyzes the last step in the synthesis of the pro-inflammatory molecule leukotriene B4 Rattus norvegicus
metabolism LTA4H catalyzes the last step in the synthesis of the pro-inflammatory molecule leukotriene B4 Canis lupus familiaris