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Literature summary for 3.3.2.6 extracted from

  • Rao, N.L.; Riley, J.P.; Banie, H.; Xue, X.; Sun, B.; Crawford, S.; Lundeen, K.A.; Yu, F.; Karlsson, L.; Fourie, A.M.; Dunford, P.J.
    Leukotriene A4 hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness (2010), Am. J. Respir. Crit. Care Med., 181, 899-907.
    View publication on PubMed
Search for more literature for 3.3.2.6

Application

Application Comment Organism
pharmacology inhibition of LTA4H is a potential therapeutic strategy that can modulate key aspects of asthma Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
JNJ 26993135 a selective LTA4H inhibitor, leads to reduction of TH2 cytokines and mucin levels, and blocks mast cell production of LTB4 and suppresses airway hyperresponsiveness Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 Balb/c mice
-
Mus musculus BALB/c
-
 Balb/c mice
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Mus musculus
-
mast cell bone marrow-derived Mus musculus
-

Synonyms

Synonyms Comment Organism
leukotriene A4 hydrolase
-
 Mus musculus
LTA4H
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme inhibition blocks lung inflammation, antigen uptake by lung dendritic cells and subsequent trafficking of dendritic cells to draining lymph nodes and the lung are decreased upon enzyme inhibition Mus musculus
physiological function leukotriene A4 hydrolase is involved in recruitment of both CD4+ and CD8+ T cells to inflammation sites, as well as trafficking of dendritic cells to draining lymph nodes Mus musculus