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Literature summary for 3.3.2.6 extracted from

  • Haeggstroem, J.Z.; Tholander, F.; Wetterholm, A.
    Structure and catalytic mechanisms of leukotriene A4 hydrolase (2007), Prostaglandins Other Lipid Mediat., 83, 198-202.
    View publication on PubMed
Search for more literature for 3.3.2.6

Crystallization (Commentary)

Crystallization (Comment) Organism
the structure of LTA4H in complex with the competitive inhibitor is determined Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bestatin
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O Homo sapiens substrate for the epoxide hydrolase reaction, in addition LTA4H shows a peptidase activity (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O substrate for the epoxide hydrolase reaction, in addition LTA4H shows a peptidase activity Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
leukotriene-A4 hydrolase
-
 Homo sapiens
LTA4H
-
 Homo sapiens