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Literature summary for 3.3.2.6 extracted from

  • Orning, L.; Fitzpatrick, F.A.
    Modification of leukotriene A4 hydrolase/aminopeptidase by sulfhydryl-blocking reagents: Differential effects on dual enzyme activities by methyl-methane thiosulfonate (1999), Arch. Biochem. Biophys., 368, 131-138.
    View publication on PubMed
Search for more literature for 3.3.2.6

Activating Compound

Activating Compound Comment Organism Structure
albumin
-
 Homo sapiens
Cl-
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
leukotriene A4 pre-treatment of enzyme by methyl-methane thiosulfonate does not protect against suicide inactivation by leukotriene A4 Homo sapiens
methyl-methane thiosulfonate inhibits aminopeptidase activity and NaCl stimulates this inactivation, beta-mercaptoethanol reactivates this inactivation, bestatin protects inactivation, little effect on epoxid hydrolase activity Homo sapiens
N-ethylmaleimide weak Homo sapiens
p-hydroxymercuribenzoate bestatin protects inactivation Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc zinc protein Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
leukotriene A4 + H2O = leukotriene B4 the aminopeptidase activity is dependent upon an unmodified cysteine residue, by modifying this cysteine with a small CH3S group it is possible to separate the two enzymatic activities, the aminopeptidase activity and epoxid hydrolase activity, from each other Homo sapiens
a
leukotriene A4 + H2O = leukotriene B4 enzyme contains two partly overlapping active sites which influence each other Homo sapiens
a
leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?
leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens