Application | Comment | Organism |
---|---|---|
medicine | enzyme overexpression appears to be an early event in esophageal adenocarcinogenesis and is a potential target for the chemoprevention of esophageal adenocarcinogenesis | Homo sapiens |
medicine | enzyme overexpression appears to be an early event in esophageal adenocarcinogenesis and is a potential target for the chemoprevention of esophageal adenocarcinogenesis | Rattus norvegicus |
medicine | the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 | Homo sapiens |
medicine | the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bestatin | - |
Homo sapiens | |
bestatin | bestatin inhibits leukotriene B4 biosynthesis in the esophageal tissues | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | Homo sapiens | biosynthesis of leukotriene B4 | leukotriene B4 | - |
? | |
leukotriene A4 + H2O | Rattus norvegicus | biosynthesis of leukotriene B4 | leukotriene B4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | P30349 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Homo sapiens | - |
endothelial cell | - |
Homo sapiens | - |
epithelium | esophageal and duodenal | Homo sapiens | - |
epithelium | esophageal and duodenal | Rattus norvegicus | - |
esophagus | basal cells | Homo sapiens | - |
esophagus | basal cells | Rattus norvegicus | - |
fibroblast | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
additional information | esophageal adenocarcinoma tumor | Homo sapiens | - |
additional information | esophageal adenocarcinoma tumor | Rattus norvegicus | - |
additional information | enzyme is higher in columnar-lined esophagus, dysplastic, and total esophageal adenocarcinoma tissues than in basal cells of esophageal epithelium, however enzyme is expressed in the parabasal cells of esophageal squamous epithelium, enzyme is also overexpressed in other cancers, including colon and lung cancers | Homo sapiens | - |
additional information | esophageal aquamous epithelial cells do not express enzyme, even in the presence of reflux esophagitis | Rattus norvegicus | - |
muscle | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | - |
Homo sapiens | leukotriene B4 | - |
? | |
leukotriene A4 + H2O | - |
Rattus norvegicus | leukotriene B4 | - |
? | |
leukotriene A4 + H2O | biosynthesis of leukotriene B4 | Homo sapiens | leukotriene B4 | - |
? | |
leukotriene A4 + H2O | biosynthesis of leukotriene B4 | Rattus norvegicus | leukotriene B4 | - |
? |