Literature summary for 3.3.2.6 extracted from

Ohishi, N.; Izumi, T.; Minami, M.; Kitamura, S.; Seyama, Y.; Ohkawa, S.; Terao, S.; Yotsumoto, H.; Takaku, F.; Shimizu, T.
Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers (1987), J. Biol. Chem., 262, 10200-10205.

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Inhibitors

Inhibitors	Comment	Organism	Structure
14,15-Leukotriene A4	-	Homo sapiens
HgCl2	-	Homo sapiens
leukotriene A4	suicide inactivation	Homo sapiens
leukotriene A4 methyl ester	-	Homo sapiens
N-ethylmaleimide	-	Homo sapiens
PCMB	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	-	Homo sapiens
0.013	0.014	leukotriene A4	pH 7.8, 37°C	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
49000	50000	gel filtration	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
leukotriene A4 + H2O	Homo sapiens	biosynthesis of leukotriene B4	leukotriene B4	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
2	3	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
leukotriene A4 + H2O	-	Homo sapiens	leukotriene B4	-	?
leukotriene A4 + H2O	biosynthesis of leukotriene B4	Homo sapiens	leukotriene B4	-	?

Subunits

Subunits	Comment	Organism
monomer	1 * 68000-70000, SDS-PAGE	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0005	-	HgCl2	pH 7.8, 37°C	Homo sapiens
0.0007	-	PCMB	pH 7.8, 37°C	Homo sapiens
3	-	NEM	pH 7.8, 37°C	Homo sapiens

pI Value

Organism	Comment	pI Value Maximum	pI Value
Homo sapiens	chromatofocusing	-	5.1

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Release 2023.1 (January 2023)