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Literature summary for 3.3.2.6 extracted from
- Purification and characterization of human lung leukotriene A4 hydrolase (1990), Methods Enzymol., 187, 286-295.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 7,11-trans-9-cis-Leukotriene A4 | - |
Homo sapiens |  |
| 7-trans-9,11-cis-Leukotriene A4 | - |
Homo sapiens | |
| ammonium sulfate | - |
Homo sapiens | |
| HgCl2 | - |
Homo sapiens | |
| KCl | - |
Homo sapiens | |
| leukotriene A4 methyl ester | - |
Homo sapiens | |
| N-ethylmaleimide | - |
Homo sapiens | |
| PCMB | - |
Homo sapiens | |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| additional information | enzyme is unstable in aqueous buffer solutions at pH 7.8 and 25°C and nonenzymatically hydrolysed, half-life less than 10 s | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| neutrophil | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.22 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, stable for at least 1 month | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + H2O | - |
Homo sapiens | leukotriene B4 | - |
? | |
| additional information | neutrophil LTA4 hydrolase also converts LTA5 to LTB5, less efficiently than LTA4 to LTB4 | Homo sapiens | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
unstable in aqueous buffer solutions at pH 7.8, half-life less than 10 s | Homo sapiens |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
unstable in aqueous buffer solutions at 25°C, half-life less than 10 s | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0005 | - |
HgCl2 | pH 7.8, 37°C | Homo sapiens | |
| 0.0007 | - |
PCMB | pH 7.8, 37°C | Homo sapiens | |
| 3 | - |
NEM | pH 7.8, 37°C | Homo sapiens | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | chromatofocusing | - |
5.1 |
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