Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxy-tamoxifen | - |
Homo sapiens | |
6-ketocholestanol | - |
Homo sapiens | |
7-ketocholestanol | - |
Homo sapiens | |
7-ketocholesterol | - |
Homo sapiens | |
alpha-linolenic acid | - |
Homo sapiens | |
amiodarone | - |
Homo sapiens | |
arachidonic acid | - |
Homo sapiens | |
cholestane-3beta,5alpha,6beta-triol | - |
Homo sapiens | |
clomiphene | - |
Homo sapiens | |
docosahexaenoic acid | - |
Homo sapiens | |
haloperidol | - |
Homo sapiens | |
N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine | - |
Homo sapiens | |
oleic acid | - |
Homo sapiens | |
raloxifene | - |
Homo sapiens | |
SR31747A | - |
Homo sapiens | |
tamoxifen | - |
Homo sapiens | |
terbinafine | - |
Homo sapiens | |
tesmilifene | - |
Homo sapiens | |
trifluoroperazine | - |
Homo sapiens | |
U-18666A | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | Homo sapiens | - |
5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O | Homo sapiens | better substrate | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
intestinal epithelium | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | richest source tissue | Homo sapiens | - |
lung | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | - |
Homo sapiens | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O | better substrate | Homo sapiens | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
anti-estrogen binding site | cholesterol epoxide hydrolase is a heterooligomeric complex called the anti-estrogen binding site comprising 3beta-hydroxysterol-DELTA8-DELTA7-isomerase and 3beta-hydroxysterol-DELTA7-reductase | Homo sapiens |
ChEH | - |
Homo sapiens |
cholesterol epoxide hydrolase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000006 | - |
SR31747A | pH and temperature not specified in the publication | Homo sapiens | |
0.000027 | - |
N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine | pH and temperature not specified in the publication | Homo sapiens | |
0.000034 | - |
tamoxifen | pH and temperature not specified in the publication | Homo sapiens | |
0.000036 | - |
raloxifene | pH and temperature not specified in the publication | Homo sapiens | |
0.000062 | - |
tesmilifene | pH and temperature not specified in the publication | Homo sapiens | |
0.00009 | - |
U-18666A | pH and temperature not specified in the publication | Homo sapiens | |
0.000135 | - |
trifluoroperazine | pH and temperature not specified in the publication | Homo sapiens | |
0.000145 | - |
4-hydroxy-tamoxifen | pH and temperature not specified in the publication | Homo sapiens | |
0.000733 | - |
amiodarone | pH and temperature not specified in the publication | Homo sapiens | |
0.0042 | - |
7-ketocholesterol | pH and temperature not specified in the publication | Homo sapiens | |
0.0091 | - |
terbinafine | pH and temperature not specified in the publication | Homo sapiens | |
0.0097 | - |
cholestane-3beta,5alpha,6beta-triol | pH and temperature not specified in the publication | Homo sapiens | |
0.012 | - |
docosahexaenoic acid | pH and temperature not specified in the publication | Homo sapiens | |
0.018 | - |
haloperidol | pH and temperature not specified in the publication | Homo sapiens | |
0.024 | - |
arachidonic acid | pH and temperature not specified in the publication | Homo sapiens | |
0.036 | - |
alpha-linolenic acid | pH and temperature not specified in the publication | Homo sapiens | |
0.054 | - |
oleic acid | pH and temperature not specified in the publication | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays a potential role in cancer progression and resistance | Homo sapiens |