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Literature summary for 3.3.2.11 extracted from

  • Segala, G.; de Medina, P.; Iuliano, L.; Zerbinati, C.; Paillasse, M.R.; Noguer, E.; Dalenc, F.; Payre, B.; Jordan, V.C.; Record, M.; Silvente-Poirot, S.; Poirot, M.
    5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of tamoxifen in breast cancer cells (2013), Biochem. Pharmacol., 86, 175-189.
    View publication on PubMed
Search for more literature for 3.3.2.11

Inhibitors

Inhibitors Comment Organism Structure
1-(2-(4-benzylphenoxy)ethyl)pyrrolidin hydrochloride
-
 Homo sapiens
tamoxifen
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O Homo sapiens
-
 5alpha-cholestane-3beta,5alpha,6beta-triol
-
 ?
5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O Homo sapiens
-
 5alpha-cholestane-3beta,5alpha,6beta-triol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O
-
 Homo sapiens 5alpha-cholestane-3beta,5alpha,6beta-triol
-
 ?
5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O
-
 Homo sapiens 5alpha-cholestane-3beta,5alpha,6beta-triol
-
 ?

Synonyms

Synonyms Comment Organism
ChEH
-
 Homo sapiens
cholesterol-5,6-epoxide hydrolase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000599
-
 pH and temperature not specified in the publication Homo sapiens tamoxifen
0.000765
-
 pH and temperature not specified in the publication Homo sapiens 1-(2-(4-benzylphenoxy)ethyl)pyrrolidin hydrochloride