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Literature summary for 3.3.2.10 extracted from

  • Mangels, N.; Awwad, K.; Wettenmann, A.; Dos Santos, L.R.; Froemel, T.; Fleming, I.
    The soluble epoxide hydrolase determines cholesterol homeostasis by regulating AMPK and SREBP activity (2016), Prostaglandins Other Lipid Mediat., 125, 30-39 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene EPHX2, quantitative real-time PCR expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of sEH-/- knockout mice, phenotype compared to wild-type, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid i.e. t-AUCB Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-

Organism

Organism UniProt Comment Textmining
Mus musculus P34914
-
-
Mus musculus C57BL/6 P34914
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(9Z)-12,13-epoxyoctadecenoic acid + H2O
-
Mus musculus (9Z)-12,13-dihydroxyoctadecenoic acid
-
?
(9Z)-12,13-epoxyoctadecenoic acid + H2O
-
Mus musculus C57BL/6 (9Z)-12,13-dihydroxyoctadecenoic acid
-
?
additional information the sEH is a dual function enzyme that generates dihydroxy-fatty acids via its C-terminal hydrolase domain, while the N-terminal phosphatase domain has been proposed to have lipid phosphatase activity, bifunctional epoxide hydrolase 2 includes cytosolic epoxide hydrolase 2, sEH, EC 3.3.2.10, and lipid-phosphate phosphatase, EC 3.1.3.76 Mus musculus ?
-
?
additional information the sEH is a dual function enzyme that generates dihydroxy-fatty acids via its C-terminal hydrolase domain, while the N-terminal phosphatase domain has been proposed to have lipid phosphatase activity, bifunctional epoxide hydrolase 2 includes cytosolic epoxide hydrolase 2, sEH, EC 3.3.2.10, and lipid-phosphate phosphatase, EC 3.1.3.76 Mus musculus C57BL/6 ?
-
?

Synonyms

Synonyms Comment Organism
SEH
-
Mus musculus

General Information

General Information Comment Organism
malfunction deletion of sEH decreases expression of HMG-CoA reductase, fatty acid synthase, and low density lipoprotein receptor. Sterol regulatory element binding proteins (SREBPs) regulate the expression of all three enzymes and SREBP activation is attenuated in the absence of sEH. The effect is attributed to the AMPK-activated protein kinase (AMPK) which is activated in the absence of sEH. Livers from wild-type versus sEH-/- littermates contain significantly higher levels of the sEH substrate 12,13-epoxyoctadecenoic acid, which elicits dAMPK activation, while the corresponding sEH product is inactive. Thus, AMPK activation and subsequent inhibition of SREBP can account for the altered expression of lipid metabolizing enzymes in sEH-/- mice Mus musculus