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Literature summary for 3.3.2.10 extracted from
- Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors (2015), Bioorg. Med. Chem. Lett., 25, 1705-1708 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(4-fluorobenzene-1-sulfonyl)amino]piperidine-1-carboxamide | - |
Homo sapiens |  |
| (3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(4-fluorobenzene-1-sulfonyl)amino]piperidine-1-carboxamide | - |
Rattus norvegicus | |
| (3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(methanesulfonyl)amino]piperidine-1-carboxamide | - |
Homo sapiens | |
| (3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(methanesulfonyl)amino]piperidine-1-carboxamide | - |
Rattus norvegicus | |
| 3-[4-[(1-[[(1R,3S)-2,2-dimethyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Homo sapiens | |
| 3-[4-[(1-[[(1R,3S)-2,2-dimethyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Rattus norvegicus | |
| 3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Homo sapiens | |
| 3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Rattus norvegicus | |
| 3-[4-[(1-[[(1S,2R,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Homo sapiens | |
| 3-[4-[(1-[[(1S,2R,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Rattus norvegicus | |
| 3-[4-[(1-[[(1s,2R,3S)-2,3-bis(4-fluorophenyl)cyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Homo sapiens | |
| 3-[4-[(1-[[(1s,2R,3S)-2,3-bis(4-fluorophenyl)cyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Rattus norvegicus | |
| 3-[4-[(1-[[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Homo sapiens | |
| 3-[4-[(1-[[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Rattus norvegicus | |
| 3-[4-[(1-[[(1S,2S,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Homo sapiens | |
| 3-[4-[(1-[[(1S,2S,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | - |
Rattus norvegicus | |
| additional information | design and synthesis of three substituted cyclopropyl urea derivatives as strong sEH inhibitors using X-ray co-crystal structure of sEH catalytic domain and 3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid, overview. cis-Configuration together with a phenyl group result in increased human and rat sEH inhibitory activity with minimal species difference | Homo sapiens | |
| additional information | design and synthesis of three substituted cyclopropyl urea derivatives as strong sEH inhibitors using X-ray co-crystal structure of sEH catalytic domain and 3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid, overview. cis-Configuration together with a phenyl group result in increased human and rat sEH inhibitory activity with minimal species difference | Rattus norvegicus | |
| N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-4-methylpiperazine-1-carboxamide | - |
Homo sapiens | |
| N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-4-methylpiperazine-1-carboxamide | - |
Rattus norvegicus | |
| N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]piperidine-1-carboxamide | - |
Homo sapiens | |
| N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]piperidine-1-carboxamide | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P34913 | - |
- |
| Rattus norvegicus | P80299 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SEH | - |
Homo sapiens |
| SEH | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000002 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(4-fluorobenzene-1-sulfonyl)amino]piperidine-1-carboxamide | |
| 0.0000002 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]piperidine-1-carboxamide | |
| 0.0000007 | - |
pH and temperature not specified in the publication | Homo sapiens | (3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(4-fluorobenzene-1-sulfonyl)amino]piperidine-1-carboxamide | |
| 0.0000008 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(methanesulfonyl)amino]piperidine-1-carboxamide | |
| 0.0000014 | - |
pH and temperature not specified in the publication | Homo sapiens | (3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(methanesulfonyl)amino]piperidine-1-carboxamide | |
| 0.0000018 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]piperidine-1-carboxamide | |
| 0.0000021 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[4-[(1-[[(1s,2R,3S)-2,3-bis(4-fluorophenyl)cyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
| 0.0000023 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[4-[(1-[[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
| 0.0000032 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-[(1-[[(1s,2R,3S)-2,3-bis(4-fluorophenyl)cyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
| 0.0000039 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-[(1-[[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
| 0.0000117 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-[(1-[[(1S,2R,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
| 0.000012 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[4-[(1-[[(1S,2R,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
| 0.0000144 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-4-methylpiperazine-1-carboxamide | |
| 0.0000191 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
| 0.0000277 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-4-methylpiperazine-1-carboxamide | |
| 0.0000556 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
| 0.0000757 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[4-[(1-[[(1S,2S,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
| 0.0001 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[4-[(1-[[(1R,3S)-2,2-dimethyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
| 0.0001 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-[(1-[[(1R,3S)-2,2-dimethyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
| 0.0001 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-[(1-[[(1S,2S,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid | |
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