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Literature summary for 3.3.2.10 extracted from
- Soluble epoxide hydrolase: gene structure, expression and deletion (2013), Gene, 526, 61-74.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | because of its central physiological role in disease states such as cardiac hypertrophy, diabetes, hypertension, and pain, the enzym is used as a therapeutic target | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K55R | the mutant has reduced phosphatase activity compared to the wild type. The mutant is associated with the risk of developing coronary heart disease in Caucasians, but not African Americans | Homo sapiens |
| R287Q | the mutant has decreased epoxide hydrolase and phosphatase activity compared to the wild type. The mutant is associated with lower vascular resistance in response to bradykinin in black, but not white Americans | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| microsome | - |
Homo sapiens | - |
- |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| peroxisome | - |
Homo sapiens | 5777 | - |
| soluble | - |
Homo sapiens | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 62000 | - |
2 * 62000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P34913 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| pulmonary artery | - |
Homo sapiens | - |
| theca cell | - |
Homo sapiens | - |
| vasculature | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoic acid + H2O | - |
Homo sapiens | 14,15-dihydroxyeicosatrienoic acid | - |
? |  |
| leukotoxin + H2O | - |
Homo sapiens | leukotoxin-1,2-diol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 62000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SEH | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | there is a significant reduction in protein expression in renal and liver malignant neoplasms compared to healthy tissue | down |
| Homo sapiens | homocysteine significantly upregulates enzyme mRNA expression. PPARgamma activation is linked to enzyme expression in human endothelial cells. Angiotensin-II treatment of HUVECs results in an over 2fold increase in mRNA expression | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme single nucleotide polymorphisms are associated with cardiovascular disease | Homo sapiens |
| physiological function | through its metabolism of the epoxyeicosatrienoic acids and other lipid mediators, the enzyme contributes to the regulation of vascular tone, nociception, angiogenesis and the inflammatory response. The enzyme plays a role in either the initiation of corpus luteum formation, and/or in the regression of the structure. The enzyme is implicated in the pathology of pulmonary hypertension | Homo sapiens |
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