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Literature summary for 3.3.2.10 extracted from

  • Amano, Y.; Yamaguchi, T.; Tanabe, E.
    Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography (2014), Bioorg. Med. Chem., 22, 2427-2434.
    View publication on PubMed
Search for more literature for 3.3.2.10

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
using 0.1 M potassium phosphate, pH 7.5, 0.2 M ammonium dihydrogen phosphate, and 22% (w/v) polyethylene glycol PEG3350 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-(1-cyclopropylethyl)-3-phenylurea
-
 Homo sapiens
2-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazole
-
 Homo sapiens
2-cyclopentyl-N-(1,3-thiazol-2-yl)acetamide
-
 Homo sapiens
3-(2-amino-1,3-thiazol-4-yl)-5-methyl-1-(tetrahydrofuran-2-ylmethyl)-1H-pyrrol-2-ol
-
 Homo sapiens
4-benzyl-3,4-dihydroquinoxalin-2(1H)-one
-
 Homo sapiens
5-(4-bromobenzyl)-1,3-thiazol-2-amine
-
 Homo sapiens
5-methyl-N-(2-phenylethyl)-4,5-dihydro-1,3-thiazol-2-amine
-
 Homo sapiens
6-(trifluoromethyl)-1,3-benzothiazol-2-amine
-
 Homo sapiens
6-amino-1-methyl-5-(piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
N,N'-dicyclohexylurea
-
 Homo sapiens
N-adamantyl-N'-cyclohexylurea
-
 Homo sapiens
N-[2-(morpholin-4-yl)phenyl]thiophene-3-carboxamide
-
 Homo sapiens
trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P34913
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, Ni-NTA column chromatography, Q-Sepharose column chromatography, and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0063
-
 in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C Homo sapiens 5-methyl-N-(2-phenylethyl)-4,5-dihydro-1,3-thiazol-2-amine
0.0074
-
 in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C Homo sapiens 1-(1-cyclopropylethyl)-3-phenylurea
0.015
-
 in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C Homo sapiens 2-cyclopentyl-N-(1,3-thiazol-2-yl)acetamide
0.029
-
 in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C Homo sapiens 6-amino-1-methyl-5-(piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione
0.049
-
 in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C Homo sapiens 6-(trifluoromethyl)-1,3-benzothiazol-2-amine
0.061
-
 in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C Homo sapiens 4-benzyl-3,4-dihydroquinoxalin-2(1H)-one
0.07
-
 in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C Homo sapiens 5-(4-bromobenzyl)-1,3-thiazol-2-amine
0.127
-
 in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C Homo sapiens 2-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazole
0.171
-
 in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C Homo sapiens N-[2-(morpholin-4-yl)phenyl]thiophene-3-carboxamide
0.195
-
 in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C Homo sapiens 3-(2-amino-1,3-thiazol-4-yl)-5-methyl-1-(tetrahydrofuran-2-ylmethyl)-1H-pyrrol-2-ol