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Literature summary for 3.3.2.10 extracted from

  • Thalji, R.K.; McAtee, J.J.; Belyanskaya, S.; Brandt, M.; Brown, G.D.; Costell, M.H.; Ding, Y.; Dodson, J.W.; Eisennagel, S.H.; Fries, R.E.; Gross, J.W.; Harpel, M.R.; Holt, D.A.; Israel, D.I.; Jolivette, L.J.; Krosky, D.; Li, H.; Lu, Q.; Mandichak, T.; Roethke, T.; Schnackenberg, C.G.; Schwartz, B.; Shewchuk, L.M.
    Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase (2013), Bioorg. Med. Chem. Lett., 23, 3584-3588.
    View publication on PubMed
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
1-[2-methyl-6-(methylamino)pyridin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[2-methyl-6-(methylamino)pyrimidin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[3-methyl-5-(methylamino)phenyl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4,6-bis(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-(dimethylamino)-6-methyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-(methylamino)-6-phenyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-cyclohexyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-ethyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethoxy)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[3-(trifluoromethoxy)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[[[4-bromo-2-(trifluoromethoxy)]-phenyl]methyl]-4-piperidinecarboxamide
-
 Rattus norvegicus
1-[4-methyl-6-(methylamino)pyridin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-methyl-6-(methylamino)pyrimidin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-methyl-6-(morpholin-4-yl)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-methyl-6-(propan-2-ylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-[(2-methoxyethyl)amino]-6-methyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[4-[[2-(dimethylamino)ethyl](methyl)amino]-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[6-methyl-2-(methylamino)pyrimidin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
1-[6-methyl-4-(methylamino)pyridin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
 Rattus norvegicus
methyl 3-chloro-4-[([[6-(3,3,3-trifluoropropoxy)pyridin-3-yl]carbonyl]amino)methyl]benzenesulfinate
-
 Rattus norvegicus
methyl 4-[([[1-butyl-2-(3,4,5-trimethoxyphenyl)-1H-benzimidazol-5-yl]carbonyl]amino)methyl]-3-methoxybenzenesulfinate
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
 Rattus norvegicus
N-(2-cyanobenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
-
 Rattus norvegicus
N-(2-methoxybenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
-
 Rattus norvegicus
N-(2-methylbenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
-
 Rattus norvegicus
N-benzyl-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
-
 Rattus norvegicus
N-[4-fluoro-2-(trifluoromethyl)benzyl]-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phenyl-oxiranyl-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000001
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-cyclohexyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.000001
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-(methylamino)-6-phenyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.000001
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-(dimethylamino)-6-methyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.000001
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-methyl-6-(propan-2-ylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.000001
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-methyl-6-(morpholin-4-yl)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.000001
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-[(2-methoxyethyl)amino]-6-methyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.000001
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethoxy)benzyl]piperidine-4-carboxamide
0.000001
-
 pH and temperature not specified in the publication Rattus norvegicus N-(2-methoxybenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
0.000003
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.000003
-
 pH and temperature not specified in the publication Rattus norvegicus N-[4-fluoro-2-(trifluoromethyl)benzyl]-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
0.000004
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-ethyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.000005
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[2-methyl-6-(methylamino)pyrimidin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.00001
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-methyl-6-(methylamino)pyridin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.00002
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4,6-bis(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.000032
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[3-methyl-5-(methylamino)phenyl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.00004
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.00004
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[6-methyl-2-(methylamino)pyrimidin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.00008
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-[[2-(dimethylamino)ethyl](methyl)amino]-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.00008
-
 pH and temperature not specified in the publication Rattus norvegicus N-(2-cyanobenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
0.000126
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[2-methyl-6-(methylamino)pyridin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.00016
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-methyl-6-(methylamino)pyrimidin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.0002
-
 pH and temperature not specified in the publication Rattus norvegicus N-(2-methylbenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
0.0002
-
 pH and temperature not specified in the publication Rattus norvegicus N-benzyl-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
0.0004
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[3-(trifluoromethoxy)benzyl]piperidine-4-carboxamide
0.00063
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[3-(trifluoromethoxy)benzyl]piperidine-4-carboxamide
0.001585
-
 pH and temperature not specified in the publication Rattus norvegicus 1-[6-methyl-4-(methylamino)pyridin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
0.0016
-
 pH and temperature not specified in the publication Rattus norvegicus N-(2-methoxybenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide